facilitates the combination of RAS proteins from the endoplasmic reticulum membrane.
Abrogation of insulinlike growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation
and receptor glycosylation pathways.
As both GGOH and farnesol (FOH) are engaged in protein prenylation
more concern should be laid on the importance of these compounds in AD pathogenesis.
of olvetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol.
In addition to cholesterol, the pathway generates several other molecules relevant to general cellular metabolism, such as farnesyl pyrophosphate and geranyl-geranyl pyrophosphate, essential in the prenylation
of a variety of proteins including the small GTPase Ras, which play a critical role in cell-cycle progression.
These modifications occur in proteins that induce cancers, and scientists believe that drugs that block protein prenylation
can be a means to prevent the spread of the disease in an individual.
The MVAP is responsible for the synthesis of many essential molecules required for cell signaling, membrane integrity, energy homeostasis, protein prenylation
, and glycosylation [55-58].
Bordier BB, Marion PL, Ohashi K, Kay MA, Greenberg FIB, Casey JL, Glenn JS (2002) A prenylation
inhibitor prevents production of infectious hepatitis delta virus particles.
Statin therapy and autoimmune diseases: from protein prenylation
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation
of GTP-binding proteins, including ras.
Conversely, another in vitro study has shown that statins stimulate endothelial detachment and MP release by inhibiting prenylation
Maeda T, Kawane T, Horiuchi N, Statins augment vascular endothelial growth factorexpression in osteoblastic cells via inhibition of protein prenylation