preimplantation genetic diagnosis

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preimplantation genetic diagnosis (PGD)

in assisted reproductive technology, the determination of chromosomal abnormalities in the embryo before it is transferred to the uterus.

preimplantation genetic diagnosis

In assisted reproduction, the testing of a fertilized egg for heritable illnesses before the ovum is inserted into the female.
See also: diagnosis

preimplantation genetic diagnosis

The use of genetic analysis in the course of vitro fertilization to ensure that a baby does not possess a known genetic defect of either parent. After analysis of the embryos formed, only those free of defect are implanted in the mother's womb. A new method, developed in 2006, involves taking a single cell from the IVF embryo, amplifying the entire genome to provide many copies, and then comparing the chromosome containing the known family mutation with those of other family members by standard DNA fingerprinting techniques.
References in periodicals archive ?
In recent years, preimplantation genetic screening (PGS) has significantly improved the frequency of healthy births in couples with genetic abnormalities.
In vitro fertilization with preimplantation genetic screening.
assembles a group of specialists in obstetrics and gynecology, reproductive medicine, and reproductive endocrinology and infertility, from the US, India, Brazil, and Germany who contribute 35 chapters on infertility, its diagnosis in men and women, its treatment with in vitro fertilization (IVF), and aspects of the IVF laboratory, such as protocols, handling embryo transfers, freezing, and biopsy for preimplantation genetic screening.
About GSN and Parental Support: GSN's proprietary Preimplantation Genetic Screening technology has been published in the leading medical journal Human Reproduction, and is more comprehensive than other existing methods used to detect chromosome abnormalities during in vitro-fertilization (IVF).
AMSTERDAM -- A new genetic screen of zygotes performed a few hours after in vitro fertilization has advantages over conventional preimplantation genetic screening, particularly in patients with a very poor prognosis, based on results of the first clinical application of the procedure.
Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF.
The technique involved, preimplantation genetic screening (PGS), takes a single cell from the multiple embryos created outside the body as part of fertility treatment.
71) Nonetheless, it continues to be carried out, (72) and should it be successful, the preimplantation genetic screening technology currently applied primarily to select preembryos based on certain health-related traits (73) could plausibly one day allow for selection or even modification based on sexual orientation.
The scenario in question involved preimplantation genetic screening to determine whether a child might be a genetic match for a sick sibling: there was no presumption in this scenario that the child himself or herself would benefit.
In collaboration with some of the world's leading in vitro fertilization (IVF) centers, BlueGnome developed 24sure[TM], a preimplantation genetic screening (PGS) test for counting the chromosomes in a single human cell - a test that holds enormous promise for increasing IVF success rates.
Reprogenetics, the worldwide largest genetics laboratory specializing in Preimplantation Genetic Screening (PGS), has announced new research demonstrating for the first time a clear association between the level of mitochondrial DNA (mtDNA) and the ability of a human embryo to implant in the uterus following infertility treatment.
As for clinical implications, the lack of a significant reduction in the miscarriage rate for infertile patients who underwent PGD with IVF suggests that other confounding infertility factors may mask potential benefits from preimplantation genetic screening (PCS) to identify abnormal embryos, Dr.