preimplantation genetic diagnosis


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Related to preimplantation genetic diagnosis: Designer babies

preimplantation genetic diagnosis

In assisted reproduction, the testing of a fertilized egg for heritable illnesses before the ovum is inserted into the female.
See also: diagnosis

preimplantation genetic diagnosis

The use of genetic analysis in the course of vitro fertilization to ensure that a baby does not possess a known genetic defect of either parent. After analysis of the embryos formed, only those free of defect are implanted in the mother's womb. A new method, developed in 2006, involves taking a single cell from the IVF embryo, amplifying the entire genome to provide many copies, and then comparing the chromosome containing the known family mutation with those of other family members by standard DNA fingerprinting techniques.
References in periodicals archive ?
These technologies are also subject to even more complex ethical problems when they are used for preimplantation genetic diagnosis to select embryos that have genetic characteristics specific to a gene complex known as human leukocyte antigen (HLA), which is in a small region of chromosome 6.
Preimplantation genetic diagnosis (PGD) is a technique which allows polar body/cell genetic status assessment obtained from an embryo/oocyte biopsy in order to detect aneuploidy or mutated alleles of monogenic diseases [16].
ESHRE PGD Consortium 'Best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)'.
Any patient with such a mutation who has not yet completed childbearing should be advised that, with in vitro fertilization and preimplantation genetic diagnosis, we now have the capability to break this familial curse.
Embryonic stem cell lines are grown from frozen embryos donated by patients undergoing preimplantation genetic diagnosis (PGD) in conjunction with IVF treatment.
In 1999, the first unaffected pregnancy was reported after using preimplantation genetic diagnosis (PGD) for sickle cell anemia (82).
The uptake and outcome of prenatal and preimplantation genetic diagnosis for Huntington's disease in the Netherlands (1998-2008).
His careful analysis of the serious moral hazards of preimplantation genetic diagnosis and also donor and surrogate methods in artificial reproductive technologies is well argued.
Career: As Professor of Fertility Studies at Hammersmith Hospital, Winston led the IVF team which pioneered preimplantation genetic diagnosis, which identifies defects in human embryos, and is now famous for his work on stem cell research.
Keywords: BRCA mutation, preimplantation genetic diagnosis, human reproduction, couples, genetic inheritance
"Current Methods for Preimplantation Genetic Diagnosis." Journal of Clinical Embryology.
Born and Made: An Ethnography of Preimplantation Genetic Diagnosis. Princeton: Princeton University Press, 2006:2.