Gene name Gene Conserved 8-mer 7-mer symbol sites Chemokine Z (C-X-C motif) CXC 12 1 1 ligand 12 NOTCH-regulated ankyrin NRARP 1 1 repeat protein Astrotactin-1 ASTN1 1 1 Nasal embryonic LHRH NELF 1 1 factor K(Lysine) acetyl KAT6B 1 1 transferase 6B Protein kinase C, alpha PRKCA 1 1 EF-hand domain family, EFHD2 1 1 member D2 Mitogen-activated protein MAP2K4 1 1 kinase kinase 4 Zinc finger protein 219 ZNF219 1 1 Ring finger protein 165 RNF165 1 1 Protocadherin 7 PCDH7 1 1 EPH receptor A3 EPHA3 1 1 Insulin receptor IRS1 1 1 substrate 1 POU class 2 homeobox 1 POU2F1
In osteosarcoma, TUG1 acted as a ceRNA by sponging miR-9-5p, inducing the upregulation of transcription factor POU2F1 (POU class 2 homeobox 1) .
Huang et al., "Long non-coding RNA TUG1 contributes to tumorigenesis of human osteosarcoma by sponging miR-9-5p and regulating POU2F1 expression," Tumour Biology, vol.
RXRA and NR1H4: retinoid X receptor and a binding partner; RORB, RORA, and RORC: retinoic acid receptor-related orphan receptors; RARB, RARG, and VDR: retinoic acid and vitamin D receptors; and CEBPB, POU2F1
, and PPARA
The gene expressions of several well-known bone formation genes including Msx2, Pxr, Pou2f1
, Cbfal, Gatal, Bmp8, Sox9, Runx2, and Alp [16-18] were not changed significantly between sfx and wild type control.
XBP1, SALL2, POU2F1, ARNT2, and MYB are the candidate drivers in preventing LVI progression (Figure S6.8).
The most interesting finding is the inferred target genes of both MYB and ARNT2 including POU2F1, SALL2, and XBP1.
One of several findings in the paper concerned POU5F1 and its archrival, POU2F1
, which binds to exactly the same eight-letter DNA sequence.
SOX2 helped both proteins bind, but it helps POU2F1
more than POU5F1.
During Adv DNA replication, host cellular proteins such as nuclear factor I and POU2F1
are used by Adv [13, 14].
Only three TFBS genes were overrepresented among loci whose methylation was associated with LINE-1 methylation: MEF2, TBX1, and POU2F1
. For those overrepresented among loci associated with AluYb8 methylation, there were a number of developmentally related TFBS genes (CUX1, CHX10, PAX4, PPARG, TAL1/ITF2 heterodimer, HAND1, MYOD, OCT), as well as those involved in cell processes (ACTR3B, S8), gene expression (NFE2L), lipid/sterol homeostasis (NR3C1), and immune modulation (GATA1).
2009), and POU2F1
(POU class 2 homeobox 1) (Glahn et al.