The net effect is a negative charge of the postsynaptic neuron
2+] in presynaptic terminals triggers glutamate exocytosis, followed by postsynaptic neuron
excitation, which induces an increase in intracellular [Ca.
d]), and also that the postsynaptic neuron
is not in an idle period, i.
The appropriate machinery for synthesizing and releasing the retrograde messenger must be located in the postsynaptic neuron
The released neurotransmitter binds to postsynaptic receptors, leading to a response in the postsynaptic neuron
1993), "cellular research has shown that the introduction of dopamine into synapses immediately after a postsynaptic neuron
has been activated by a presynaptic neuron produces long-lasting changes in synaptic efficacies.
A third variable modulating dopamine's effect is the number of dopamine receptors on the postsynaptic neuron
For a cortex-like network to operate properly, a regulation mechanism that keeps the activity level within certain bounds should be assumed (coactivation of a pre- and postsynaptic neuron
leads to synaptic strengthening).
In biology, there are processes that lead to internal neuronal changes in case of indirectly activation of the transfer channels of the postsynaptic neuron
(see  or ).
The glutamate then interacts with receptors on the surface of the postsynaptic neuron
, thereby initiating changes in that neuron that culminate in the generation of a new nerve signal in that cell.
This enhanced response persists indefinitely and is associated with changes in the density and the length of the dendrite of the postsynaptic neuron
(Kolb & Whishaw, 2003).