Peptide hormones can be categorized into the following two groups: peptides with complex post-translational modifications
followed by proteolytic processing and peptides with multiple intramolecular disulfide bonds.
This database demonstrates proteins existence, their related isoforms, post-translational modifications
as well as subcellular localization (47).
This post-translational modification
(PTM) affects the structure of the target protein.
Spellman, "O-linked fucose and other post-translational modifications
unique to EGF modules," Glycobiology, vol.
This highly dynamic post-translational modification
plays a key role in signal transduction pathways; and key contractile proteins, such as myosin heavy chain, actin and MLC also have been shown to be modified by O-GlcNAc in slow and fast skeletal muscle, as well as in VSMCs (11,13,14).
Leveraging their knowledge of the CHO-M cell line genome and transcriptome, Selexis identified potential issues with the CHO-M secretory pathways such as stalled translocation, improper folding, incomplete post-translational modifications
or insufficient cellular respiration to handle the increased protein load.
For the third edition the 2002 second edition has been updated and expanded by 57 chapters, which are spread throughout the book but primarily clustered in the section on post-translational modifications
and so reflect the increasing importance of these modifications in the understanding of protein function.
A diverse and elaborate array of post-translational modifications
including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation occurs at N-terminal histone domains.
Major post-translational modifications
like phosphorylation, acetylation, ribosylation, methylation, farnesylation, etc., create a docking surface with which the modules of other proteins and segments of DNA interact.
These large protein drugs (~150,000 Da) require post-translational modifications
and critical disulphide bonds for full activity.
also contribute to the great diversity of proteins and determine cellular localization of proteins, physiological activity, protein interactions, and protein turnover.
Both their amino acid sequence (composition) and post-translational modifications
(PTMs or attachments) are human.