A non-motile, gram-negative, anaerobic bacillus of the phylum Bacteroidetes, which forms black colonies on blood agar. It is found in the oral cavity, where it causes periodontal disease by producing collagenase, and has been cultured from gastrointestinal and respiratory tract specimens and from patients with rheumatoid arthritis.
Contributors describe the applied genomics of some oral bacteria, horizontal gene transfer in oral bacteria, cell-to-cell communication in oral microbial communities, the molecular biology of carcinogenic bacteria, molecular windows into the pathogenic properties of Aggregaribacter acinomycetemcomitans, the molecular biology of Porphyromonas gingivalis, the molecular biology of the survival and virulence of Treponema denticola, the molecular basis of host-pathogen interaction in the oral cavity and of host defense mechanisms in oral disease, and molecular approaches to vaccination against oral infections.
Porphyromonas gingivalis, Prevotella intermedia, Prevotella melaninogenica, and Bacteroides forsythus are Gram negative anaerobic bacteria and are considered to be directly responsible for the periodontitis (periodontopathic bacteria).
Periodontal disease is caused by colonization of pathogenic bacteria such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, which results in an inflammation that occurs in response to this colonization and invasion.