Porcine Heart Valve

A bioprosthetic valve obtained from pigs, which have an average 9-year lifespan (compared to 50,000 simulated years with mechanical valves), but don’t require anti-coagulation with Coumadin. Because of the limited lifespan, porcine valves are usually implanted on patients age 55 and above
References in periodicals archive ?
Seebacher et al., "Early failure of the tissue engineered porcine heart valve SYNERGRAFT in pediatric patients," European Journal of Cardio-thoracic Surgery, vol.
its key programmes, including the development of further applications of the vascular patch through preclinical and clinical studies, development of the porcine heart valve and pursue of regulatory clearance for a decellularised version of an existing bioprosthetic heart valve, advancement of existing meniscus project towards CE approval and launch of ligament development programme targeted at anterior cruciate ligament repair among other goals.
The company also distributes the CryoLife-O'Brien stentless porcine heart valve which is CE marked for distribution within the European Community.
CryoLife says SynerGraft incorporates the use of a porcine heart valve which has been depopulated of its porcine heart valve cells, providing a collagen matrix that has the normal functionality of a human heart valve, with the potential to be repopulated with the recipient's own cells.
SDS treatments have met the standard requirements of complete cell removal and elimination of at least 90% of host DNA in several types of tissues and organs, including rat forearm [58], porcine cornea [30], porcine myocardium [59], porcine heart valve [47], porcine small intestine [45], porcine kidney [34], human vein [60], rat, porcine, and human lungs [40, 46], and human heart [61].
CryoLife, Inc., Atlanta, GA, announced that two human females have each received a tissue-engineered SynerGraft porcine heart valve in the aortic position.
Under terms of the grant, CryoLife says its scientists will conduct advanced studies and animal testing on the feasibility of a new biologic human heart vale replacement which incorporates a porcine heart valve collagen matrix that can be "seeded" with human cells from the recipient to create a living autograft heart valve for human heart valve replacement surgery.
Different protocols were used for decellularization of biomaterials includes 1% triton X-100 for aortic leaflets (3) ; 0.03-1% SDS and 0.5-2% SDS for porcine heart valves (13); 0.1% SDS with nuclease enzymes for porcine bladder (14); 1% triton X-100 for porcine aortic valves (11); SDS and triton X-100 for aortic valve leaflets (12); 1% triton X-100 for embryonic bodies (15); triton X-100 for anterior cruciate ligament (16) and porcine intact bladder with triton X-100 (17).
In God is not Great, Hitchens notes uneasy similarities between humans and pigs: Porcine DNA and human DNA are very similar, so much so that porcine heart valves can be transplanted into humans; pigs are noticeably smarter than other farm animals; and pig skin looks almost human, so much so that the smell and look of suckling pig and roasting human infants is, according to those who have had the misfortune of smelling and seeing both, disconcertingly similar.
TO MARY IN WYOMING: Porcine heart valves (made from pig hearts) have been used to replace narrowed and/or leaking human aortic and mitral valves since about 1965.
The company also manufactures CryoLife-O'Brien(R) and CryoLife-Ross(TM) stentless porcine heart valves which are distributed within the European Community.
International cardiovascular surgeons will be able to access information and place orders for the CryoLife-O'Brien and CryoLife Ross stentless porcine heart valves and BioGlue surgical adhesive for vascular repair.

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