Pomin

Pomin

Diazepam, see there.
References in periodicals archive ?
Although effective against deep vein thrombosis, the prolonged use of UHEP as standard anticoagulant induces bleeding complications and thrombocytopenia because the response of individual patients is highly variable (Brieger, Mak, Kottke-Marchant, & Topol, 1998; Pineo & Hull, 1998), encouraging studies on new therapeutic tools (Athukorala, Jung, Vasanthan, & Jeon, 2006; Pomin & Mourao, 2008; Pomin, 2012; Mourao, 2015).
These marine glycans of high molecular weights (Pomin, 2012; Fidelis et al., 2014) are abundantly available in the cell-walls and intercellular space as structural components of the algae (Estevez, Ciancia, & Cerezo, 2008; Rodrigues, Torres, Alencar, Sampaio, & Farias, 2009; Miguel et al., 2014).
This therapeutic agent is mainly extracted from pig and bovine intestine and its potential risks of chemical contamination with other glycosaminoglycans for use in cardiac surgeries also justify the current efforts to develop alternatives to UHEP (Mourao & Pereira, 1999; Pomin, 2012; Rodrigues et al., 2016).
Natural products derived from aquatic organisms for functional food, biochemical research and other biotechnological applications hagve aroused special interest in recent years (POMIN; MOURAO, 2008; RODRIGUES et al., 2011b; SMIT, 2004; VANDERLEI et al., 2010).
Algae (macro and microalgae), sponges, tunicates, echinoderms, mollusks, shrimps, bacteria and fungi contain diverse classes of metabolites (e.g., sulfated polysaccharides-SPs, alkaloids, polyphenols, terpenes and glycolipids) (Ghosh et al., 2009, Vo et al., 2011, Patel, 2012) of great economical importance (Cardozo et al., 2007, Gupta & AbuAhannam, 2011, Toskas et al., 2011) to develop pharmaceutics for various diseases (Vo et al., 2011, Pomin, 2012, Mourao, 2015).
The search for algal products with relatively low toxicity for medicinal, food and/or biochemical use has significantly increased in recent times (ANANTHI et al., 2010; POMIN, 2012; SMIT, 2004; VANDERLEI et al., 2010, 2011; ZHANG et al., 2003).
angiogenesis (Cardozo et al., 2007; Pomin, 2012), coagulation (Leite et al., 1998; Rodrigues et al., 2009; Rodrigues et al., 2013), inflammation (Rodrigues et al., 2012; Smit, 2004) and infections (Mayer et al., 2007; Smit, 2004).
New biomaterials for pharmaceutical, food and cosmetic industries have been identified and studied in wild and/or cultivated algae species (ARAUJO et al., 2012; CAMPO et al., 2009; MAZUMDER et al., 2002; POMIN, 2012; PUSHPAMALI et al., 2008; RODRIGUES et al., 2011a, 2013).
Rhodophyceae biosynthesize high amounts of SPs (RODRIGUES et al., 2009; ARAUJO et al., 2012) compared with Chlorophyceae (RODRIGUES et al., 2011c, 2012) and Phaeophyceae (POMIN; MOURAO, 2008; SIQUEIRA et al., 2011) and other natural sources (AQUINO et al., 2005; POMIN; MOURAO, 2008; DANTAS-SANTOS et al., 2012; CHANG et al., 2013).
In recent years, the human consumption of seaweeds as food (thickening, gelling and stabilizing, nutrients, etc.) (CAMPO et al., 2009; MARINHO-SORIANO et al., 2006; SMIT, 2004), and the search for bioactive products (with anticoagulant, antinociceptive, anti-inflammatory effects etc.) (ARAUJO et al., 2012; POMIN, 2012; RODRIGUES et al., 2011a; VANDERLEI et al., 2010) with minimum adverse effects (ALMEIDA-LIMA et al., 2011; ASSREUY et al., 2008; LI et al., 2005; VANDERLEI et al., 2010) have increased worldwide.
Although polydispersity and heterogeneity contribute to their complexity, they have attracted the attention in glycomics (POMIN, 2012) by modulating various biological systems, such as thrombosis (FONSECA et al., 2008; RODRIGUES et al., 2011), coagulation (AMORIM et al., 2011; POMIN, 2012) and inflammation (QUINDERE et al., 2013; RODRIGUES et al., 2012b, 2014).
The biotechnological importance of natural products (e.g., phenolic compounds, sulfated polysaccharides, lectins, carotenoids and organic acids) (CORDEIRO et al., 2006; MAEDA et al., 2005; MABEAU; FLEURENCE, 1993; POMIN; MOURAO, 2008) extracted from seaweeds could motivate the industries to development of novel ingredients for commercial use not only due to their rheological aspects (e.g.