damage to biotherapeutics is discussed at length in a just published review article in the Journal of Excipients and Food Chemicals.
60 and its close relatives, polysorbate
65 and polysorbate
80, work like mono- and diglycerides.
Key advantages of these products will be: all-natural, no preservatives (such as potassium sorbate or EDTA), no undeclared additives and only GRAS, clean label ingredients for direct food use (no polysorbates
or hydrogenated castor oil PEG 40).
A universal-detection method for pharmaceutical manufacturing operations uses reverse-phase HPLC with the Corona CAD de tector for sensitive and robust analysis of polysorbates
. It is suited for speciation of the various individual components of a non-ionic mixture and for batch-to-batch comparisons to measure variations in polysorbate
composition from various sources or lots of material.
With 370 million pounds per year capacity, it will produce a broad range of non-ionic surfactants and specialty alkoxylates, such as kosher polysorbates
, amine and alcohol ethoxylates, high molecular weight PEGs and much more.
There is no need for EDTA or preservatives, there are no detergents or polysorbates
are surfactants which are formed by reacting 100% bio-based ethylene oxide with 100% bio-based sorbitan esters (Span USDA BioPreferred Certified 100% bio-based).
Super Refined[R] J.T.Baker[R] Polysorbate
20 and 80 are designed to improve solubilization and stability in a variety of biopharmaceutical and small-molecule drug formulations.
Avantor Performance Materials' Super Refined grade of polysorbate
products improve solubilization and stability in a variety of biopharmaceutical and small-molecule drug formulations.