polymyxin

(redirected from Polymyxin B)
Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to Polymyxin B: bacitracin

polymyxin

 [pol″e-mik´sin]
a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.
polymyxin B a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa, which may cause septicemia, meningitis, urinary tract infections, and middle ear infections. Toxicity is low but there is sometimes damage to kidney and nerve cells. The route of administration is parenteral, oral, or topical to the ear or eye. Oral preparations are not used for systemic infections because the drug is poorly absorbed from the intestinal tract.

pol·y·myx·in

(pol'ē-mik'sin),
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus), an organism found in water and soils and obtainable as a crystalline hydrochloride; all are polypeptides containing various amino acids and a branched-chain fatty acid, usually (+)-6-methyloctanoic acid. There are several polymyxins, (for example, designated A, B1, C, D, E, M, T), which are about equally effective against gram-negative bacteria, but which differ in toxicity, polymyxin E (colistin) and polymyxin B being the least toxic.
See also: colistimethate sodium.

polymyxin

/poly·myx·in/ (-mik´sin) generic term for antibiotics derived from Bacillus polymyxa; they are differentiated by affixing different letters of the alphabet.
polymyxin B  the least toxic of the polymyxins; its sulfate is used in the treatment of various gram-negative infections.

polymyxin

(pŏl′ē-mĭk′sĭn)
n.
Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.

pol·y·myx·in

(P) (pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa, an organism found in water and soils and obtainable as a crystalline hydrochloride.

pol·y·myx·in

(pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus).

polymyxin (pol´ēmik´sin),

n an antibiotic substance derived from cultures of
B. polymyxa. Used topically, in troche form, in combination with bacitracin and neomycin in the treatment of various oral infections. Not used systemically; therefore sensitization is minimized. Systemic use may be attended by renal dysfunction and toxicity.

polymyxin

a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.

polymyxin B
a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa and is also used against Klebsiella spp. It is used mostly in combinations with other antibiotics as a topical dressing including ophthalmic and aural preparations. It is not absorbed from the alimentary tract and is not recommended for systemic use because of its nephrotoxicity and neurotoxicity.
polymyxin E
References in periodicals archive ?
Susceptibility to polymyxin B amongst clinical CPE isolates ranges globally from 80 to 100%.
Other Experimental Conditions Tested Polymyxin B Instead of Colistin
1% were ICU Polymyxin B (11) patients); Median APACHE score = 19 (range 12-35) Souli (2010) Inpatients (64.
It seems that the most active combinations are those that add either imipenem or rifampin or both to polymyxin B," said Dr.
Polymyxin B for Injection is an Anti-Infective made use in the cure of infections of the urinary tract, meninges, bloodstream and eye caused by susceptible strains of Pseudomonas aeruginosa.
Polymyxin B resistance and biofilm formation in Vibrio cholerae are controlled by the response regulator CarR.
According to 2010 IMS data, the US market for injectable polymyxin B was approximately USD8m, added the company.
Polymyxin B was first isolated from a spore-bearing soil bacillus in 1947.
These isolates were resistant to all tested antimicrobial drugs, including polymyxin B and colistin, to which PDR isolates are normally susceptible.
In a rat model, Emgard and Hellstrom recently demonstrated that betamethasone dipropionate alone healed experimentally induced external otitis more rapidly than did hydrocortisone/oxytetracycline, with or without polymyxin B.