polymyxin

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polymyxin

 [pol″e-mik´sin]
a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.
polymyxin B a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa, which may cause septicemia, meningitis, urinary tract infections, and middle ear infections. Toxicity is low but there is sometimes damage to kidney and nerve cells. The route of administration is parenteral, oral, or topical to the ear or eye. Oral preparations are not used for systemic infections because the drug is poorly absorbed from the intestinal tract.

pol·y·myx·in

(pol'ē-mik'sin),
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus), an organism found in water and soils and obtainable as a crystalline hydrochloride; all are polypeptides containing various amino acids and a branched-chain fatty acid, usually (+)-6-methyloctanoic acid. There are several polymyxins, (for example, designated A, B1, C, D, E, M, T), which are about equally effective against gram-negative bacteria, but which differ in toxicity, polymyxin E (colistin) and polymyxin B being the least toxic.
See also: colistimethate sodium.

polymyxin

/poly·myx·in/ (-mik´sin) generic term for antibiotics derived from Bacillus polymyxa; they are differentiated by affixing different letters of the alphabet.
polymyxin B  the least toxic of the polymyxins; its sulfate is used in the treatment of various gram-negative infections.

polymyxin

(pŏl′ē-mĭk′sĭn)
n.
Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.

pol·y·myx·in

(P) (pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa, an organism found in water and soils and obtainable as a crystalline hydrochloride.

pol·y·myx·in

(pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus).

polymyxin (pol´ēmik´sin),

n an antibiotic substance derived from cultures of
B. polymyxa. Used topically, in troche form, in combination with bacitracin and neomycin in the treatment of various oral infections. Not used systemically; therefore sensitization is minimized. Systemic use may be attended by renal dysfunction and toxicity.

polymyxin

a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.

polymyxin B
a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa and is also used against Klebsiella spp. It is used mostly in combinations with other antibiotics as a topical dressing including ophthalmic and aural preparations. It is not absorbed from the alimentary tract and is not recommended for systemic use because of its nephrotoxicity and neurotoxicity.
polymyxin E
References in periodicals archive ?
Polymixin inhibited 98% of isolates, which is similar to figures found by Haeili et al 2013 (1) who observed 95.
Bacitracin has been associated with cases of contact dermatitis in the conjunctival area, and the polymixin B combinations can also cause local irritation.
The study Polymixin B Sulfate (CAS 1405-20-5) Market Research Report 2012' presents an overview of the Polymixin B Sulfate market globally and regionally by contemplating and analyzing its parameters.
Contract Awarded for Supply of Polymixin B for injection.
aeruginosa isolates were sensitive to ofloxacin, amikacin, meropenem, pieracillin/tazobactam and polymixin B, while sensitivity to ceftazidime, gentamycin and tetracyclin was 75%, 50% and 0% respectively.
Imipenem, meropenem, ceftazidime, ciprofloxacin, gentamicin, cefepime, amikacin, polymixin B, and piperacillin/tazobactam were used to evaluate susceptibility of P.
Now the posterior aspect of this assembly is reflected forwards and the middle ear is packed with gel foam soaked in neomycin, polymixin B and hydrocortisone (Neosporin H).
baumannii count for approximately 4 log comparing to the effect of polymixin B as a single agent (Fig.
1% Spersadex Prednisolone acetate Pred Forte 18 - 36 40 1% Combined preparations Betamethasone, Betnesol N 36 - 54 neomycin Dexamethasone, Covomycin D 36 - 54 chloramphenicol Fluoromethalone, FML-Neo neomycin Dexamethasone, Maxitrol 36 -54 neomycin, polymyxin B Dexamethasone, Sofradex 36 - 54 framycetin, gramicidin Dexamethasone, Spersadex Comp 36 - 54 chloramphenicol Hydrocortisone, Terra-Cortril 8 - 12 oxytetracycline, polymixin B Dexamethasone, Tobradex 36 - 54 tobramycin Drugs in order of Side-effect Indications increasing potency Single preparations Worsening Allergic keratoconjunctivitis, Prednisolone acetate of external inflamed pterygium, 0.
coli N10-0505 were susceptible to colistin, polymixin B, and tigecycline.
All these isolates were sensitive to amoxicillin, chloramphenicol, neomycine, oxytetracycline, streptomycine, and polymixin B.
were defined as 'panresistant' if they are resistant to all six available anti-pseudomonal classes of antimicrobial agents, namely anti-pseudomonal penicillins, cephalosporins, carbapenems, monobactams, quinolones and aminoglycosides and polymyxins except from polymixin B (16).