polymyxin

(redirected from Polymixin)
Also found in: Dictionary, Thesaurus, Encyclopedia.

polymyxin

 [pol″e-mik´sin]
a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.
polymyxin B a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa, which may cause septicemia, meningitis, urinary tract infections, and middle ear infections. Toxicity is low but there is sometimes damage to kidney and nerve cells. The route of administration is parenteral, oral, or topical to the ear or eye. Oral preparations are not used for systemic infections because the drug is poorly absorbed from the intestinal tract.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pol·y·myx·in

(pol'ē-mik'sin),
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus), an organism found in water and soils and obtainable as a crystalline hydrochloride; all are polypeptides containing various amino acids and a branched-chain fatty acid, usually (+)-6-methyloctanoic acid. There are several polymyxins, (for example, designated A, B1, C, D, E, M, T), which are about equally effective against gram-negative bacteria, but which differ in toxicity, polymyxin E (colistin) and polymyxin B being the least toxic.
See also: colistimethate sodium.
Farlex Partner Medical Dictionary © Farlex 2012

polymyxin

(pŏl′ē-mĭk′sĭn)
n.
Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

pol·y·myx·in

(P) (pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa, an organism found in water and soils and obtainable as a crystalline hydrochloride.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

pol·y·myx·in

(pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus).
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
The Colistin and Polymixin B were found equally effective againstAcinetobacter spp.
Abbreviations used; Amp, Ampicillin; Am, Amoxicillin; Baci, Bacitracin; Clii, Chioramphenicol; Eiy, Erythromycin; I, intermediate; Kan, Kanamycin; Neo, Neomycin; Nal, Nalidiaxic acid, Oxytet, Oxytetracyclin; P.mix, Polymixin; R, resistant; 5, sensitive; Strep, Streptomycin; Tet Cyc, Tetracyclin; and Van, Vancomycin.
Isolates which were resistant to all classes including the glycicyclins and polymixins were labelled as PDR.
Furthermore, these effects were not seen with boiled CRP or after CRP pretreatment with an anti-CRP antibody, and they were not abrogated with polymixin B (data not shown).
Polymixin B is active only against gram-negative bacteria and therefore is given in combination with other antibiotics, including trimethoprim, bacitracin, and neomycin/bacitracin, which broaden the coverage to include staphylococci, streptococci, and some gramnegative bacteria including H.
The group I was treated as control group and antiseptic dressing of surgical wound was carried out with Povidone iodine and local application of Polymixin B sulphate, Neomycin sulphate and Zinc Bacitracin ointment, Inj.
For preparing the MGIT culture tubes (Becton Dickinson, Maryland, USA), a vial of 15 mL OADC enrichment (oleic acid, albumin, dextrose and catalase) was well-mixed with a vial of PANT antibiotics (polymixin B, amphotericin B, nalidixic acid, trimethoprim, azlocillin) before culturing and 0.8 ml was added to each MGIT culture medium by an insulin syringe.
Imipenem, meropenem, ceftazidime, ciprofloxacin, gentamicin, cefepime, amikacin, polymixin B, and piperacillin/tazobactam were used to evaluate susceptibility of P.
Now the posterior aspect of this assembly is reflected forwards and the middle ear is packed with gel foam soaked in neomycin, polymixin B and hydrocortisone (Neosporin H).
baumannii count for approximately 4 log comparing to the effect of polymixin B as a single agent (Fig.
Combination of antibiotic (Bacitracin and Polymixin) and steroid (0.05% Betamethasone valerate) ointments was used to protect the donor site for three months.