polymerase

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polymerase

 [pah-lim´er-ās]
an enzyme that catalyzes polymerization.
polymerase chain reaction a rapid technique for in vitro amplification of specific DNA or RNA sequences, allowing small quantities of short sequences to be analyzed without cloning.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pol·ym·er·ase

(pol-im'ĕr-ās),
General term for any enzyme catalyzing a polymerization, as of nucleotides to polynucleotides, thus belonging to EC class 2, the transferases.
Farlex Partner Medical Dictionary © Farlex 2012

polymerase

(pə-lĭm′ə-rās′, -rāz′, pŏl′ə-mə-)
n.
Any of various enzymes, such as DNA polymerase, RNA polymerase, or reverse transcriptase, that catalyze the formation of polynucleotides of DNA or RNA using an existing strand of DNA or RNA as a template.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

POLA1

A gene on chromosome Xp22.1-p21.3 that encodes the catalytic subunit of DNA polymerase that plays a key role in initiating DNA replication.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

pol·ym·er·ase

(pŏ-lim'ĕr-ās)
General term for any enzyme catalyzing a polymerization, as of nucleotides to polynucleotides, thus belonging to EC class 2, the transferases.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

polymerase

Any enzyme that promotes the linkage of a number of similar or identical chemical subunits into repetitive long-chain molecules (polymers), especially of NUCLEOTIDES to form DNA or RNA. Derivation as in POLYMER with the -ase suffix denoting an enzyme.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

polymerase

an enzyme that catalyses the joining of DNA or RNA nucleotides.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Gerlach, The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance, National Acad Sciences, 5681 (2000).
Mismatch extension of DNA polymerases and high-accuracy single nucleotide polymorphism diagnostics by gold nanoparticle-improved isothermal amplification.
Keywords: MDBK-T7 cells, T7 RNA polymerase, lentivirus, stable expression, puromycin selection.INTRODUCTION
Both employ a pair of template-specific complementary primers to define the ends of the sequence to be amplified: these primers act to recruit and initiate polymerase function in making new product strands.
Hogrefe, "PCR fidelity of Pfu DNA polymerase and other thermostable DNA polymerases," Nucleic Acids Research, vol.
To determine whether Pol [beta], KF [exo.sup.-], Pol [beta] or each of these polymerases can accurately incorporate nucleotides after bypassing a Oz:G lesion, we analyzed nucleotide incorporation opposite the sequence TT immediately adjacent to and 5' of G or Oz.
Thermo-stability of the enzyme was compared with that of commercially available Taq polymerase. Two genes have been newly registered in the gene bank (Genbank Reference No.: EU682501, Version: EU682501.1 and AM999769.1.) and defined as Thermus aquaticus 16S ribosomal RNA gene with 1430 bp.
Another tenable explanation for the presence of multiple specialised DNA polymerases in vertebrates is that each evolved to accurately bypass a particular type of naturally occurring base damage.
"In many instances where a more accurate polymerase might work, this one could now be substituted, so more mutations will occur," Foster said.
This is a surprising suggestion, because it is thought that TLS polymerases are inaccurate and that they form mispairs that increase the mutation rate.
The activation times of 2 chemical hot start polymerases (FastStart and Amplitaq Gold) and heat-activated nucleotide analogs (CleanAmp dNTPs) were assessed.

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