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A mixture of long-chain alcohols derived from sugar cane and other natural sources. It has been promoted as a natural lipid-lowering agent. Studies sponsored by the manufacturer of policosanol have shown striking results, but no effect on lipid levels was found during an independent trial performed in Germany.

policosanol (pōˈ·lē·kōˑ·s·nl),

n a waxy derivative of sugar cane or beeswax. Has been used to reduce cholesterol levels, to treat intermittent claudication, to enhance athletic performance, and as a possible adjunct in treating Parkinson's disease. Caution is advised for patients taking antiplatelet medications, anticoagulants, levodopa, and nitroprusside. See also octacosanol.
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Resveratrol, turmeric, beta-carotene, coenzyme Q10, L-carnitine, arginine, red yeast rice, policosanol, hawthorn extract and vitamins such as C, B, E and folic acid have been promoted to reduce heart disease due to their antioxidant, anti-inflammatory and risk factor-lowering effects.
Effect of Omega-3 and Policosanol Supplementation on Attention and Reactivity in Athletes.
Phytosterols with (worthless) policosanol in a chewable wafer.
Red yeast rice, policosanol and berberine may target the HMG-CoA enzyme, reducing cholesterol synthesis, whilst berberine also targets triglyceride (TG) synthesis and low-density lipoprotein cholesterol (LDL-C) liver uptake.
I have used RYR alone or mixed with other natural supplements as policosanol, guggulipid, milk thistle (Silybum marianum), and coenzyme Q10.
180 subjects (83 females and 97 males) with mild to moderate hypercholesterolemia, (range of total cholesterol between 200 and 290 mg/dl), mild hypertension (no antihypertensive drug therapy; 140159/90-99 mm Hg systolic/diastolic blood pressure), in which low-fat diet for three months did not achieve the treatment goal, were treated also with monacolin K of red rice (10 mg, 90% in policosanol per day) and fiber glucomannan (3 g per day) for 24 weeks.
Key elements of this "proprietary cosmeceutical blend" include policosanol, derived from sugar cane; coleus oil, a minty ingredient similar to tea tree oil; monolaurin, the popular coconut oil; and vitex oil, a broad-spectrum antimicrobial.
staminensis together with the combination of policosanol, red yeast rice extract, berberine, folic acid and coenzyme Q10 have indicated an effective control of high blood pressure in patients with metabolic syndrome, thus may be served as a antihypertensive agent [25].
Other blood thinning herbs/foods that have the potential to increase the blood thinning effects of aspirin, warfarin or clopidogrel, if taken at high supplemental doses include: aloe vera, carnitine, chamomile, chondroitin, cinnamon, CoQ10, cranberry, devil's claw, dong quai, feverfew, garlic, ginger, gingko, ginseng, glucosamine, goji, grape seed extract, green tea, krill oil, policosanol, saw palmetto, turmeric, willow bark.
There are numerous supplements that can lower your cholesterol, including two I've used with my patients: Advanced Cholesterol Formula with LDL-lowering policosanol and Circutol (a total heart health formula).
Antiatherosclerotic efficacy of policosanol, red yeast rice extract and astaxanthin in the rabbit.

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