In the early 1980s in Finland, serologic evidence associated SINV with rash and arthritis, known as Pogosta disease (19).
Seroprevalence of SINV in the human population was analyzed for persons with suspected Pogosta disease; although this sample is not random and was recorded by the place of treatment (not residence), it does provide good representation of different geographic areas.
Causative agent of Pogosta disease isolated from blood and skin lesions.
Diagnostics of Pogosta disease: antigenic properties and evaluation of Sindbis virus IgM and IgG enzyme immunoassays.
Pogosta disease is a mosquito-borne viral disease in Finland, which is clinically manifested by rash and arthritis; larger outbreaks occur in 7-year intervals.
The typical clinical picture of Pogosta disease includes arthritis, maculopapular rash, and sometimes low fever, fatigue, and muscle pain (4; Kurkela et al., unpub.
The aim of this study was to isolate the causative agent of Pogosta disease directly from human samples.
We collected samples from the health districts where the incidence of Pogosta disease had been highest during previous epidemic years, North Karelia and Kuopio.
We analyzed retrospectively the use of Physician Desk Reference Database searches to identify epidemics of tularemia, nephropathy, Pogosta disease, and Lyme disease and compared the searches with mandatory laboratory reports to the National Infectious Diseases Register in Finland during 1995.
We chose four infectious diseases for comparison between PDRD searches and NIDR laboratory reports: tularemia, ICD-10 A21, caused by Francisella tularensis; epidemic nephropathy, ICD-10 A98.5, caused by a Puumala virus (a hantavirus); Pogosta disease, ICD-10 A92.8, caused by the Sindbis virus (an arbovirus); and Lyme disease, ICD-10 A69.2, caused by Borrelia burgdorferi.
The Lyme disease guideline was the third most frequently read, with 144 readings; Pogosta disease was fifth, with 91; epidemic nephropathy eighth, with 87; and tularemia nineteenth, with 68 readings.
A large epidemic of Pogosta disease took place in late summer and autumn 1995.