For kidney therapy, we will generate specific kidney cell populations with therapeutic potential such as podocytes
and tubular epithelial cells by combining emerging cutting-edge technologies from the fields of cellular reprogramming and pluripotent stem cells differentiation.
In the kidney, VEGF is produced by glomerular podocytes
and tubular epithelial cells, and bind to VEGF receptors found on mesangium, glomerular, and peritubular capillaries (Gurevich & Perazella, 2009).
CB1 receptors are also expressed in kidney cells, including podocytes
and proximal tubule cells (10-12), and we suggest that the AKI related to SCB might be related to CB1 receptors in the kidneys.
A previous study suggests that overexpression of COX-2 in podocytes
exacerbates diabetic nephropathy and treatment with a COX-2 inhibitor can reduce albuminuria and mesangial matrix expansion (Cheng et al.
A study of the effects of serum from patients with lupus nephritis on cultured human podocytes
(Manson et al)
Marcus Moeller, MD, Bart Smeets, PhD, Katja Berger (RWTH University of chen, in Germany), and their colleagues looked to see if they could coax podocytes
to be generated from putative kidney progenitor cells- termed parietal cells- as a potential treatment strategy for kidney failure.
Celecoxib modifies glomerular basement membrane, mesangium and podocytes
in 0VE26 mice, but ibuprofen is more detrimental.
Proteasome analysis of urinary exosomes has identified proteins from all segments of the nephron, including glomerular podocytes
(podocin and podocalyxin), proximal tubules (megalin, cubilin, aquaporin-1, and type IV carbonic anhydrase), thick ascending limb of Henle (type 2 Na-K-2Cl cotransporter), distal convoluted tubule (thiazide-sensitive Na-Cl cotransporter), and the collecting duct (aquaporin 2) (12).
It had long been assumed the efficacy of ACTH was a consequence of the peptide's ability to increase endogenous corticosteroid production, but evidence including those from adrenalectomized animals supports the view that steroidogenesis may only partly account for ACTH effect and that its influence is explained by binding to melanocortin receptors, which are generously expressed, for example, in renal podocytes
Natriuretic peptide receptor guanylyl cyclase-a protects podocytes
from aldosterone-induced glomerular injury.
PHILADELPHIA - The detection of urinary podocytes
in mid-pregnancy is a highly sensitive and specific marker for preeclampsia and may be the first reliable tool for predicting which women will develop the potentially life-threatening hypertensive complication, according to Dr.
are terminally differentiated cells that line the glomerular basement membrane and act as a size-selective filter that must structurally encompass the entire glomerular surface with foot processes to maintain proper filtration (Wiggins 2007).