Histologic analysis showed that lesions were similar to those observed in humans and indicated necrotizing bronchointerstitial pneumonia with type II pneumocyte
hyperplasia, abundant fibrin, and streaming mucus in airways.
Mutational and radiographic analysis of pulmonary disease consistent with lymphangioleiomyomatosis and micronodular pneumocyte
hyperplasia in women with tuberous sclerosis.
9) Pneumocystis is primarily an alveolar pathogen that does not invade the pneumocyte
to which it tightly adheres.
31) Vitamin A deficiency produces profound morphologic alterations in liver and lung parenchyma and impairs pneumocyte
type II cells in basilar alveoli is associated with delayed increase in surfactant in those alveoli.
The initial underlying pathologic process in the lung from amiodarone toxicity is postulated to be a drug-induced phospholipidosis, (9) and the mechanism by which phospholipids accumulate in the cell is believed to be by inhibition of intracellular phospholipase when the drug and its metabolites are trapped in alveolar macrophages and type II pneumocyte
At the periphery of the mycotic lesions were foci of type II pneumocyte
hyperplasia, septal fibroplasia, and mononuclear infiltration.
Note background type II pneumocyte
nuclear staining for thyroid transcription factor 1 in A (circle) (original magnifications X40).
A severe inflammatory reaction that ultimately results in both endothelial and pneumocyte
damage leads to the observed severe hypoxaemia.
1) Pulmonary lesions are less common and occur mainly as lymphangiomyomatosis and/or multifocal micronodular pneumocyte
Lamellar bodies are secreted by the type II pneumocyte
and unfold to form tubular myelin and other large aggregates that are absorbed onto the hydrated inner layer of the alveoli.
Endogenous surfactants, those which occur naturally in the lungs of the baby, are a product of the alveolar type II cell, the granular pneumocyte
, and that natural surfactant consists of 85 to 90 percent lipids and 10 percent proteins, jointly comprising surfactant as we know it, dipalmitoylphosphatidylcholine (DPPC), or lecithin.