Thus, induced pluripotent stem cells
represent a promising combination of adult and embryonic stem cell characteristics.
8220;Evaluation of high-affinity antibodies specific to pluripotent stem cells
for the diagnosis of aggressive and metastatic cancers”
Induced pluripotent stem cells
represent a promising tool for use in the reversal and repair of many previously incurable diseases.
The research objective of the project is to develop synthetic materials to control the differentiation of human pluripotent stem cells
(hPSCs) (which comprise human embryonic stem cells and induced human pluripotent stem cells
) suitable for clinical use using a combination of synthetic polymer chemistry, hPSC culture and high throughput materials characterization.
THREE-DIMENSIONAL CARDIAC TISSUE PRODUCTION USING HUMAN INDUCED PLURIPOTENT STEM CELLS
Albert Lam, MD, Benjamin Freedman, PhD, Ryuji Morizane, MD, PhD (Brigham and Women's Hospital), and their colleagues have been working for the past five years to develop strategies to coax human pluripotent stem cells
-- particularly human embryonic stem (ES) cells and human induced pluripotent stem (iPS) cell -- into kidney cells for the purposes of kidney regeneration.
The Salk findings demonstrate for the first time that pluripotent stem cells
(PSCs)-cells capable of differentiating into the many cells and tissue types that make up the body- can made to develop into cells similar to those found in the ureteric bud, an early developmental structure of the kidneys, and then be further differentiated into three-dimensional structures in organ cultures.
Researchers have discovered a new, high efficient way to produce neural stem cells from human pluripotent stem cells
(hPSCs) that can go on to form neurons in the brain.
Here, we demonstrate induction of pluripotent stem cells
from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions.
Pluripotent stem cells
are cells that have the ability to differentiate into any cell in the human body.
Topics include engineering the pluripotent stem cell
niche for directed mesoderm differentiation, cell mechanobiology in regenerative medicine, systems-engineering principles in signal transduction and cell-fate choice, biomaterial scaffolds for human embryonic stem cell culture and differentiation, stem cells and regenerative medicine in the nervous system, stem cells and regenerative medicine for treating damaged myocardium, synthetic biomaterials and stem cells for connective tissue engineering, and derivation and expansion of human pluripotent stem cells
Harnessing the potential of induced pluripotent stem cells
for regenerative medicine.