pluripotency


Also found in: Dictionary, Wikipedia.

pluripotency

/plu·rip·o·ten·cy/ (-po´ten-se)
1. the ability to develop or act in any one of several possible ways.
2. the ability to affect more than one organ or tissue.plurip´otentpluripoten´tial
References in periodicals archive ?
OCT4 is a crucial and dependent determinant of pluripotency in ES and EC cells (10).
The researchers looked at the molecular signals that control TET activity to understand more about how the activity of the TET enzymes can be manipulated during cellular programming to achieve pluripotency.
They identified two distinct patterns of DNA methylation, indicating different stages of reprogramming, and showed that individual cells with the later-stage (pluripotency) pattern also expressed late pluripotency genetic markers.
The capacity for self-renewal and the pluripotency of ESCs is known to be controlled by the transcription factors, Nanog homeobox (NANOG), octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2), and signaling pathways like leukemia inhibitory factor (LIF)-signal transducer and activator of transcription 3 (STAT3) and bone morphogenic protein (BMP)-Mothers against decapentaplegic homolog (SMAD) 1/4/5/8 (Rodda et al.
iPSCs generated from the mouse cells have been shown to possess basic features of pluripotency like the ability to express stem cell markers, differentiating into various tissue types [7].
29 in the journal Nature detailed research showing success with a process called stimulus-triggered acquisition of pluripotency, or STAP.
Haruko Obokata, the leader of the study, and her all female research team reported they have discovered a new phenomenon, known as stimulus-triggered acquisition of pluripotency (STAP).
Certain stem cells can be easily grown in the laboratory and can turn into any type of cell in the body, which is called pluripotency.
Haruko Obokata, 30, stating that the young women had shown great talent and initiative in discovering the new phenomenon, known as stimulus-triggered acquisition of pluripotency (STAP).
Even though hESCs have been studied extensively over the last decade due to their potential to differentiate into cell-types of potential clinical applications, little is known about the role that splicing plays in the regulation of pluripotency in these cells.
We confirmed pluripotency of ciPSCs using the following techniques: (i) immunostaining and quantitative PCR for the presence of pluripotent and germ layer-specific markers in differentiated ciPSCs; (ii) microarray analysis that demonstrates similar gene expression profiles between ciPSCs and canine embryonic stem cells; (iii) teratoma formation assays; and (iv) karyotyping for genomic stability.
The first volume begins with explanation of advances in the field as well as definitions, criteria and standards for 'stemness,' the molecular circuitry underlying pluripotency in embryonic stem cells and iPS cells, and mechanisms of stem cell self-renewal.