plumbagin


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plumbagin

Herbal medicine
A natural yellow pigment found in plants of the Plumbagineae and Droseracea families, which is a redox-cycling agent that also induces DNA cleavage. In animal and cell model systems, plumbagin has anti-atherosclerotic, anticarcinogenic, anti-inflammatory, antifertility, antimalarial, antimicrobial, cardiotonic,
immunosuppressive and neuroprotective effects.
References in periodicals archive ?
In this study, trifluralin, acriflavine, saponin and plumbagin were used in alternate combination of two drugs against L.
Elimination of multidrug-resistant plasmid in bacteria by plumbagin, a compound derived from a plant.
The activity of plumbagin and other electron carriers against Leishmania donovani and Leishmania mexicana amazonensis.
NF-[kappa]B inhibition was also described in the anti-metastatic activities of plumbagin against MDA-MB-231 and HepG2 liver cancer cells as well (Shih et al.
The anthelmintic effect of plumbagin on Schistosoma mansoni.
Plant secondary compounds like Plumbagin isolated from Pera benensis exhibited its effectivity via increased generation of free radicals in parasites; however, its ability to induce mammalian topoisomerase II mediated DNA cleavage suggests its potential cytotoxicity towards host cells (Fournet et al.
Since however, plumbagin, a 2-methyljuglon, also acts synergistically together with INH, and since it is known that plumbagin increases the superoxide concentration intracellularly and so transforms IN into its active form, the action with 7-MJ could be analogous (Bulatovic et al.
Totarol ferulenol and plumbagin were observed to increase the potency of isonicotinic acid hydrazide by fourfold against Mycobacterium sp.
Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats.
tuberculosis, exhibited increased susceptibility to INH when combined with plumbagin (2-methyljuglone), another naphthoquinone with similar structure, indicating synergistic activity.
The active principle of Plumbago rosea, the plumbagin, has been reported to stimulate the granulocytes in vitro at pico to femto gram range, while at higher doses it results in the immunosuppressive activity (Wagner et al.
Plumbagin, a known isolate from Plumbago species administered to hyperlipidaemic rabbits reduced serum cholesterol (Sharma et al.