Also found in: Dictionary, Thesaurus, Wikipedia.
Related to Plavix: Clopidogrel, aspirin

clopidogrel bisulfate


Pharmacologic class: Platelet aggregation inhibitor

Therapeutic class: Antiplatelet drug

Pregnancy risk category B

FDA Box Warning

• Effectiveness of clopidogrel depends on activation to an active metabolite by the cytochrome P(CYP) 450 system, principally CYP2C19.

• Patients identified as CYP2C19 poor metabolizers treated with clopidogrel at recommended dosages exhibit higher cardiovascular event rates following acute coronary syndrome or percutaneous coronary intervention than patients with normal CYP2C19 function.

• Tests are available to identify a patient's CYP2C19 genotype and can be used as an aid in determining therapeutic strategy.

• Consider alternative treatment or treatment strategies in patients identified as CYP2C19 poor metabolizers.


Inhibits platelet aggregation by blocking binding of adenosine diphosphate to platelets, thereby preventing thrombus formation


Tablets: 75 mg, 300 mg

Indications and dosages

Recent myocardial infarction (MI) or stroke or established peripheral arterial disease

Adults: 75 mg/day P.O.

Acute coronary syndrome (ACS)

Adults: 300 mg P.O. as a loading dose, then 75 mg/day P.O. in combination with aspirin (75 to 325 mg once daily) for patients with non-ST-segment elevation ACS (unstable angina, non-ST-elevation MI)

Adults: 75 mg P.O. once daily in combination with aspirin (75 to 325 mg once daily), with or without a loading dose and with or without thrombolytics for patients with ST-elevation MI


• Hypersensitivity to drug
• Active pathologic bleeding


Use cautiously in:
• thrombotic thrombocytopenic purpura
• increased risk of bleeding
• concomitant use of drugs that inhibit CYP2C19 (such as esomeprazole, omeprazole)
• concomitant use of aspirin in patients with recent transient ischemic attack or cerebrovascular accident
• premature discontinuation of drug
• pregnant or breastfeeding patients
• children (safety and efficacy not established).


• Give with or without food.
• Know that drug may need to be discontinued 5 days before surgery.

Adverse reactions

CNS: depression, dizziness, fatigue, headache

CV: chest pain, hypertension

EENT: epistaxis, rhinitis

GI: diarrhea, abdominal pain, dyspepsia, gastritis, GI bleeding

Hematologic: bleeding, neutropenia, thrombotic thrombocytopenic purpura

Metabolic: hypercholesterolemia, gout

Musculoskeletal: joint pain, back pain

Respiratory: cough, dyspnea, bronchitis, upper respiratory tract infection, bronchospasm

Skin: pruritus, rash, angioedema

Other: hypersensitivity reactions, anaphylactic reactions


Drug-drug.Abciximab, aspirin, eptifibatide, heparin, heparinoids, nonsteroidal anti-inflammatory drugs (NSAIDs), thrombolytics, ticlopidine, tirofiban, warfarin: increased risk of bleeding

CYP2C19 inhibitors (such as esomeprazole, omeprazole): significantly reduced clopidogrel antiplatelet activity

Fluvastatin, many NSAIDs, phenytoin, tamoxifen, tolbutamide, torsemide: interference with metabolism of these drugs

Drug-diagnostic tests.Bilirubin, hepatic enzymes, nonprotein nitrogen, total cholesterol, uric acid: increased levels

Platelets: decreased count

Drug-herbs.Anise, arnica, chamomile, clove, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng: increased risk of bleeding

Patient monitoring

• Monitor hemoglobin and hematocrit periodically.
• Monitor patient for unusual bleeding or bruising; drug significantly increases risk of bleeding.
• Assess for occult GI blood loss if patient is receiving naproxen concurrently with clopidogrel.

Patient teaching

• Tell patient to take tablets with or without food.

Advise patient to immediately report unusual or acute chest pain, respiratory difficulty, rash, purplish bruises on skin or in mouth, purple skin patches, unusual fatigue, fast heart rate, confusion, signs and symptoms of stroke (including weakness on one side, speech changes), low urine output, unresolved bleeding, diarrhea, GI distress, nosebleed, or acute headache.

Instruct patient not to discontinue drug without consulting prescriber.
• Instruct patient to tell all health care providers that he's taking clopidogrel, especially if surgery is scheduled or new drugs are prescribed.
• Advise patient to contact prescriber before taking over-the-counter products, particularly nonsteroidal anti-inflammatory drugs.
• Tell patient drug may cause headache and dizziness. Caution him to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Advise patient to minimize adverse GI effects by eating small, frequent meals or chewing gum.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above.


A trademark for the drug clopidogrel bisulfate.

Plavix ®

Clopidogrel bisulfate Cardiology An antiplatelet agent used to ↓ risk of stroke, acute MI, or vascular death in Pts with known ASHD. See CAPRIE.


A brand name for the antiplatelet drug CLOPIDOGREL.
References in periodicals archive ?
TTP, sometimes fatal, has been reported following use of PLAVIX, sometimes after a short exposure (<2 weeks).
Cost, time in market and generic Plavix were identified as three issues that could dissuade physicians from writing ticagrelor.
Plavix is expected to face competition in 2012 from lower-cost, generic versions of the drug when its patents expire.
Additionally, only 8 percent of emergency room physicians perceive Effient to be superior to Plavix for reducing clinical events.
In the CURE trial, patients with unstable angina (UA) and non-ST segment elevation myocardial infarction (NSTEMI) receiving PLAVIX with ASA were followed for up to one year, 10 and in the CAPRIE trial, patients with recent MI, recent ischemic stroke, or established peripheral artery disease receiving PLAVIX alone were followed for up to three years.
Bristol Myers Squibb is at the beginning of its patent cliff that is expected to negatively impact sales during 2012 - 2013 of two top-selling pharmaceuticals, Plavix and Avapro, which represented 36.
com is offering a 30-day supply of generic Plavix or Clopidogrel for $35, including free shipping nationwide.
Sales were led by double-digit jumps in sales for Plavix and HIV treatments Reyataz and Sustiva.
In the meantime, I agree with your being treated with the Plavix and aspirin.
NYSE: MHS) gene testing analysis found that 38 percent of patients prescribed Plavix (clopidogrel)-an anti-platelet drug used to prevent blood clots, heart attack and stroke-were also using another drug that would impede its effectiveness.
The team studied pharmacy data on Plavix or clopidogrel, the $9 billion-a-year seller made by France's Sanofi-Aventis SA and Bristol-Myers Squibb Co.
The article reports that 41% of patients in the GRAVITAS trial had high on-treatment platelet reactivity after receiving Plavix.