Platinol


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Related to Platinol: cisplatin

Platinol

 [plat´ĭ-nol]
trademark for a preparation of cisplatin, an antineoplastic agent.

Platinol

(plăt′ə-nôl′, -nŏl′)
A trademark for the drug cisplatin.

Platinol

a trademark for an antineoplastic (cisplatin).

cisplatin

A chemotherapeutic that forms covalent bonds and crosslinks with DNA, which is used for head and neck, ovarian, testicular, and bladder cancers and lymphomas.

Adverse effects
Nephrotoxicity, nausea, sensory neuropathy.

Management for adverse effects
• Nephrotoxicity: adequate hydration to maintain renal flow and high chloride concentration.
• Nausea: ondansetron, a selective antagonist of serotonin S3 receptors.
• Neuropathy: amifostine, growth factors, glutathione, Org 2766, acetyl-L-carnitine, vitamin E have all been tried; per Cochrane review, none proved effective; more studies are needed.
References in periodicals archive ?
Platinum, Taxanes and Doxorubicin are widely employed drugs in the treatment of cancer that include Platinol (cisplatin) and Paraplatin (carboplatin) (marketed by Bristol-Myers Squibb), paclitaxel (Taxol(R) marketed by Bristol-Myers Squibb), docetaxel (Taxotere(R) marketed by Sanofi Aventis) and doxorubicin (Adriamycin marketed by Bedford Laboratories).
Note: Taxol(R), Paraplatin(R) and Platinol AQ(R) are registered trademarks of Bristol-Myers Squibb Company; Taxotere(R) is a registered trademark of Aventis; and Onxol(TM) is a trademark of IVAX Research, Inc.
The FTC found that 'each of these patent listings [for Buspar, Taxol and Platinol that were the subject of the complaint] was improper and unlawful because the patent did not meet the statutory listing criteria'," Ms.
Bristol-Myers Squibb announced today that it has reached an agreement with the Federal Trade Commission on the terms of a proposed consent decree that would resolve antitrust proceedings relating to BuSpar(R), TAXOL(R) and Platinol.