Platinol


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Related to Platinol: cisplatin

Platinol

 [plat´ĭ-nol]
trademark for a preparation of cisplatin, an antineoplastic agent.

Platinol

(plăt′ə-nôl′, -nŏl′)
A trademark for the drug cisplatin.

Platinol

a trademark for an antineoplastic (cisplatin).

cisplatin

A chemotherapeutic that forms covalent bonds and crosslinks with DNA, which is used for head and neck, ovarian, testicular, and bladder cancers and lymphomas.

Adverse effects
Nephrotoxicity, nausea, sensory neuropathy.

Management for adverse effects
• Nephrotoxicity: adequate hydration to maintain renal flow and high chloride concentration.
• Nausea: ondansetron, a selective antagonist of serotonin S3 receptors.
• Neuropathy: amifostine, growth factors, glutathione, Org 2766, acetyl-L-carnitine, vitamin E have all been tried; per Cochrane review, none proved effective; more studies are needed.
References in periodicals archive ?
In another action, the Commission charged that Bristol-Myers Squibb Company (Bristol) engaged in a series of anticompetitive acts over the past decade to obstruct the entry of low-price generic competition for three of its widely-used pharmaceutical products: two anticancer drugs, Taxol and Platinol, and the antianxiety agent BuSpar.
The postoperative diagnosis was low-grade ESS, for which the patient was treated with 3 courses of CAP (cyclophosphamide, Adriamycin [doxorubicin], and Platinol [cisplatin]) at doses of 300, 30, and 50 mg/[m.
Methotrexate and Cytoxan (cyclophosphamide) are associated with more moderate hair loss, and it's rare to have alopecia with Platinol AQ (cisplatin) use.