PF4

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Related to Platelet factor 4: heparin, platelet factor 3

PF4

A gene on chromosome 4q12-q21 that encodes a protein released from the alpha-granules of activated platelets which binds with high affinity to heparin. PF4’s major physiologic role appears to be neutralisation of heparin-like molecules on the endothelial surface of blood vessels, inhibiting antithrombin-III activity and promoting coagulation; as a chemoattractant for neutrophils and fibroblasts, PF4 likely plays a role in inflammation and wound repair.
References in periodicals archive ?
Further evidence that alpha-granule components such as platelet factor 4 are involved in platelet-IgG-heparin interactions during heparin-associated thrombocytopenia.
Platelet activation is measurable by quantifying thromboxanes, platelet factor 4, and thrombomodulin (TM).
A substantial portion of future sales will continue to depend on receipt of FDA and EU approvals, and approvals for the heparin platelet factor 4 and white blood cell tests are expected in 2004.

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