platelet activating factor


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Related to platelet activating factor: Cytokines

platelet activating factor

A factor which, like PROSTAGLANDINS and LEUKOTRIENES, is released from cell membranes. It is a potent cause of INFLAMMATION and an activator of several cell types of the immune system. It is rapidly destroyed and its effect is local.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Andrikopoulos, "Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor," Biochemistry International, vol.
Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo.
Background & objectives: Despite the established pro-inflammatory actions of platelet activating factor (PAF) observed on chronic obstructive pulmonary disease (COPD), its action on airway remodeling has been still unclear.
We show that indomethacin while not affecting the LPS-induced enhancement in cPL[A.sub.2]-catalyzed arachidonic acid release, caused inhibition in prostaglandin [E.sub.2] (PG[E.sub.2]) production, up-regulation in apoptosis and platelet activating factor (PAF) generation, and potentiation of the impairment in mucin synthesis.
IS Lp-PL[A.sub.2] ALSO KNOWN AS PLATELET ACTIVATING FACTOR (PAF) ACETYLHYDROLASE] "FRIEND OR FOE"?
Compounds biologically similar to platelet activating factor are present in stored blood components.
Kleinjnen and Knipschild reviewed the literature of controlled trials, mostly from Europe, which examined the vasoregularity activity and platelet activating factor antagonism of ginkgo biloba.
Thereafter, several vasoconstricting and collagen degrading products, such as histamine, platelet activating factor, cytokines, chemokines, neutral proteases (tryptase, chymase), and renin are released into circulation.