plakoglobin


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plakoglobin

A protein encoded by JUP on chromosome 17q21, which is the core molecule in the submembranous plaques of desmosomes and intermediate junctions, and forms complexes with cadherins. It is a member of the catenin protein family as it contains a so-called armadillo repeat.

Interactions
Beta-catenin, MUC1, CDH1, CDH2, CDH3, E-cadherin, desmoglein 2, desmoplakin.

Abnormal in 
JUP mutations are associated with arrhythmogenic right ventricular cardiomyopathy and Naxos syndrome.
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References in periodicals archive ?
VE-cadherin and the armadillo family protein plakoglobin regulate vascular endothelial permeability and growth.
BmARM-Like Protein from Silkworm, Bombyx mori (Lepidoptera) is Putatively Involved in Response against BmNPV Infection
Naxos syndrome is correlated with a homozygous deletion of two base pairs found in the plakoglobin gene located in the 17q21.2 locus (Table 1) [11, 23].
Arrhythmogenic right ventricular cardiomyopathy: an overview and update
Ben-Zeev, "Differential mechanisms of LEF/TCF family-dependent transcriptional activation by [beta]-catenin and plakoglobin," Molecular and Cellular Biology, vol.
Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer
Usefulness of immunostaining for plakoglobin as a diagnostic marker of arrhythmogenic right ventricular cardiomyopathy.
A Brief Review and Update of the Clinicopathologic Diagnosis of Arrhythmogenic Cardiomyopathy
The plakoglobin, desmoplakin and desmocollin-2 are family members of desmosomal proteins that function as cell-cell adhesion junction, and are expressed in skin, heart and hair.5
Identification of LIPH gene mutation in a consanguineous family segregating the woolly hair/hypotrichosis phenotype
The probable molecular mechanism hypothesized was that by mutating desmosomal protein impairs desmosomal assembly releasing free plakoglobin from the desmosomes, which could translocate into the nucleus and through competition with [beta]-catenin suppress signaling through the canonical Wnt/ [beta]-catenin-Tcf/Lef pathway.
Comparison of Uhl's anomaly, right ventricular outflow tract ventricular tachycardia (RVOT VT) & arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) with an insight into genetics of ARVD/C
Plakoglobin and [beta]-catenin: distinct but closely related.
Expression of cell adhesion molecules in the normal and T3 blocked development of the tadpole's kidney of Bufo arenarum (Amphibian, Anuran, Bufonidae)/ Expressao das moleculas de adesao celular no desenvolvimento normal e com a inibicao do hormonio tireoidea do rim nas larvas do Bufo arenarum (Amphibia, Anura, Bufonidae)
Whereas the cadherins in most AJs are linked to the actin cytoskeleton through [alpha]-and [beta]-catenin, desmosomal cadherins recruit the armadillo proteins plakoglobin and plakophilin-1, which are vertebrate-specific gene duplications related to [beta]-catenin and are linked to the intermediate filament cytoskeleton either directly or via the linker protein desmoplakin (Schneider et al., 2003).
Cell-cell adhesion in the cnidaria: insights into the evolution of tissue morphogenesis
Gumbiner, "A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin," Science, vol.
The Effect of Pyrroloquinoline Quinone on the Expression of WISP1 in Traumatic Brain Injury
Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin. J Cell Biol.
Beta-catenin forms protein aggregation at high concentrations in HEK293TCells
In mouse models, knockdown of plakoglobin abrogates CTC cluster formation and suppresses lung metastases (18).
Clinical significance of circulating tumor microemboli as a prognostic marker in patients with pancreatic ductal adenocarcinoma
They went on to demonstrate that overexpression of DSP led to increased plakoglobin ([gamma]-catenin).
Proteomic Analysis of Oral Cavity Squamous Cell Carcinoma Specimens Identifies Patient Outcome-Associated Proteins

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