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plakoglobinA protein encoded by JUP on chromosome 17q21, which is the core molecule in the submembranous plaques of desmosomes and intermediate junctions, and forms complexes with cadherins. It is a member of the catenin protein family as it contains a so-called armadillo repeat.
Beta-catenin, MUC1, CDH1, CDH2, CDH3, E-cadherin, desmoglein 2, desmoplakin.
JUP mutations are associated with arrhythmogenic right ventricular cardiomyopathy and Naxos syndrome.