placental site trophoblastic tumor


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pla·cen·tal site troph·o·blas·tic tu·mor

a tumor usually arising in the uterus of parous women during reproductive years. Histologically, the tumor consists of a predominance of intermediate trophoblastic cells with fibrinoid material and vascular invasion.

placental site trophoblastic tumor

Gynecologic pathology
A rare uterine neoplasm of gestational tissue of reproductive age ♀, presenting as a 'missed' abortion, which ranges from microscopic to massive and from 'timid' to highly aggressive that actively secretes human placental lactogen Prognosis 10% mortality

placental site trophoblastic tumor

Abbreviation: PSTT
A rare form of gestational trophoblastic disease simulating carcinoma and arising at the attachment of the placenta to the uterine wall.
See also: tumor
References in periodicals archive ?
Placental site trophoblastic tumor is a space-occupying lesion involving endomyometrium, and patients usually present with vaginal bleeding or amenorrhea with mild elevation of serum hCG months or years after full-term pregnancy or abortion.
Abbreviations: ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs; PSTTs, placental site trophoblastic tumors (original magnifications X400).
However, placental site trophoblastic tumors and epithelioid trophoblastic tumors have true blood vessels that provide a blood supply inside the tumor, instead of the vasculogenic mimicry formed by EVTs.
The diagnosis of hydatidiform mole is clinically important because of its potential to give rise to persistent gestational trophoblastic disease including invasive mole, choriocarcinoma and placental site trophoblastic tumors. Furthermore, the distinction between complete and partial mole is also significant.8