IGFBP1

(redirected from Placental protein 12)

IGFBP1

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP1 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid se quence with somatomedin binding protein from human amniotic fluid.

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