PiZZ


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PiZZ

The most common variant allele in α1-antitrypsin deficiency; the common normal allele is PiMM. See α1-antitrypsin deficiency.
References in periodicals archive ?
In a Danish study on never-smoking non-index cases of phenotype PiZZ, no abnormalities in lung function could be identified (Seersholm et al.
The 2D-PAGE analysis of PIZZ patient plasma showed changes in the intensity and pI of all the [[alpha].
First, the list of expressions created can now be reordered-although the display is not designed for over 100 of them--which allows, for example, tempo indications to be grouped separately from performance method indications (such as arco and pizz.
The company's study consists of two parts: Part A in healthy volunteers, which has been completed; and Part B to be conducted in patients with PiZZ genotype AATD.
Homozygous PiZZ is also associated with liver involvement and confers a risk for liver disease, but only a minority of people with this genotype develop cholestasis and/or cirrhosis (2, 4, 5).