Piriton


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chlorpheniramine maleate

Ahist, Allercalm (UK), Allerief (UK), Calimol (UK), Chlorphen, Chlor-Trimeton, Chlor-Trimeton Allergy 4 Hour, Chlor-Trimeton Allergy 8 Hour, Chlor-Trimeton Allergy 12 Hour, Chlor-Tripolon (CA), Diabetic Tussin Allergy Relief, Novo-Pheniram (CA), Piriton (UK), Teldrin HBP

Pharmacologic class: Propylamine (nonselective)

Therapeutic class: Antihistamine; allergy, cold, and cough remedy

Pregnancy risk category B

Action

Antagonizes effects of histamine at histamine2-receptor sites, preventing histamine-mediated responses

Availability

Capsules (sustained-release): 8 mg, 12 mg

Syrup: 1 mg/5 ml, 2 mg/5 ml, 2.5 mg/5 ml

Tablets: 4 mg, 8 mg, 12 mg

Tablets (chewable): 2 mg

Tablets (timed-release): 8 mg, 12 mg

Indications and dosages

Allergy symptoms; management of anaphylaxis and transfusion reactions

Adults: 4 mg q 4 to 6 hours P.O. or 8 to 12 mg P.O. of sustained-release form q 8 to 12 hours. Maximum dosage is 24 mg/day.

Children ages 6 to 12: 2 mg P.O. q 4 to 6 hours daily. Maximum dosage is 12 mg/day.

Dosage adjustment

• Glaucoma

• Gastric ulcer

• Hyperthyroidism

• Heart disease

Contraindications

• Hypersensitivity to drug

• Acute asthma attacks

• Stenosing peptic ulcer

• Breastfeeding

Precautions

Use cautiously in:

• hepatic or renal disease, asthma, angle-closure glaucoma, prostatic hypertrophy

• elderly patients

• pregnant patients (safety not established).

Administration

• Don't crush or break timed-release tablets or sustained-release capsules.

• Discontinue drug 4 days before allergy skin tests. (Drug may cause false-negative reactions.)

Adverse reactions

CNS: dizziness, drowsiness, excitation (in children), sedation, poor coordination, fatigue, confusion, restlessness, nervousness, tremor, headache, hysteria, tingling sensation, sensation of heaviness and weakness in hands

CV: palpitations, hypotension, bradycardia, tachycardia, extrasystoles, arrhythmias

EENT: blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, nasal congestion, dry nose, dry throat, sore throat

GI: nausea, vomiting, diarrhea, constipation, epigastric distress, anorexia, dry mouth, GI obstruction

GU: urinary retention, urinary hesitancy, dysuria, early menses, decreased libido, erectile dysfunction

Hematologic: hemolytic anemia, hypoplastic anemia, thrombocytopenia, leukopenia, pancytopenia, agranulocytosis

Respiratory: thickened bronchial secretions, chest tightness, wheezing

Skin: urticaria, rash, photosensitivity, diaphoresis

Other: chills, increased appetite, weight gain, anaphylactic shock

Interactions

Drug-drug. Anticholinergics, anti-cholinergic-like drugs (such as some antidepressants, atropine, haloperidol, phenothiazines, quinidine, disopyramide): additive anticholinergic effects

CNS depressants (such as opioids, sedative-hypnotics): additive CNS depression

MAO inhibitors: intensified, prolonged anticholinergic effects

Drug-diagnostic tests. Allergy skin tests: false-negative reactions

Drug-behaviors. Alcohol use: additive CNS depression

Sun exposure: photosensitivity

Patient monitoring

• Assess for urinary retention and frequency.

• Monitor respiratory status throughout therapy.

Patient teaching

• Advise patient to take with full glass of water.

• Tell patient not to crush timed-release tablets or sustained-release capsules. Instruct him to swallow them whole.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Advise parents to give dose to children in evening, because morning doses may cause inattention in school.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

Piriton

A brand name for the ANTIHISTAMINE drug CHLORPHENIRAMINE (chlorphenamine).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
These are just like the Piriton hay fever tablets for humans, except that they are weaker, a lot smaller and ten times as expensive.
He did take Piriton syrup, an antihistamine used to treat allergy, and used an inhaler which they also kept in the house.
We are now only two more cool baths, a dose of Piriton and a quart of after-sun away from normality.
Anti-histamines such as Piriton block allergic reactions for a short period, calming your dog and reducing the need to scratch.
These include Piriton, for allergic reactions, two antibiotics, an anti-inflammatory, plus medicines to treat abdominal pain and stop vomiting.
Their eyes were washed out and they were given Piriton tablets.
Use decongestants such as Sudafed or antihistamines such as Piriton to relieve the blockage or discharge from your nose and sinuses with advice from pharmacist.
I divide the remaining products into two broad groups: the old fashioned ones like Piriton and Phenergan which cause drowsiness, and the modern ones like loratidine (Clarityn), fexofenadine (Telfast) and cetirizine (Zirtek), which are more expensive, but are longer acting and much less sedative.
Wanda has to carry piriton tablets and an adrenaline needle pen with her everywhere she goes.