Table-1: Substituents of 4-(4-Bromophenyl)-4- hydroxy piperdine.
The results showed that parent compound 4-(4'-Bromophenyl)-4-hydroxy piperdine exhibited no inhibitory response whereas significant activity was shown by the compounds, 1-(1''-Adamantan acyl)-4- (4'- bromophenyl)-4-hydroxy piperidinium Hydrobromide (I) This kind of exhibition due to the substitution of adamantane group in molecule and adamantine is responsible for causing the modulation of neurotransmitter Furthermore quarternization with piperidine ring made it more suitable for cholinergic activity .
Whether a peppercorn is green, black, white or pink, there is one factor that remains constant for all four varieties: their pungency, derived from three elements; resin, piperdine
and volatile oil.
Summary: The present study was conducted to evaluate the synthesized 4-(4'-Bromophenyl)-4- hydroxy piperdine
derivatives for plasmepsin inhibition (antimalarial activity) and analgesic response to develop excellent moiety to work in malaria.