piperazine

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piperazine

 [pi-per´ah-zēn]
an anthelmintic used in various salts against Ascaris lumbricoides and Enterobius vermicularis.

pi·per·a·zine

(pī-per'ă-zēn, -zin),
A veterinary anthelmintic and filaricide.
Synonym(s): diethylenediamine

piperazine

/pi·per·a·zine/ (-zēn) an anthelmintic used against Ascaris lumbricoides and Enterobius vermicularis; used as the citrate salt.

piperazine

(pī-pĕr′ə-zēn′, pĭ-)
n.
1. An organic compound, C4H10N2, that is used (often in the form of a salt) as an anthelmintic in humans and domestic animals and is widely used in the manufacture of pharmaceuticals, synthetic resins, polyurethane, and other industrial products.
2. Any of various derivatives of this compound, some of which have stimulant and hallucinogenic properties.

piperazine

An ANTHELMINTIC drug used to get rid of ROUNDWORMS and THREADWORMS. The drug paralyses the worms which are then passed with the faeces. A brand name for the drug formulated with the laxative senna is Pripsen.

pi·per·a·zine

(pī-per'ă-zēn, -zin)
A veterinary anthelmintic and filaricide.
Synonym(s): diethylenediamine.

piperazine (piper´əzēn),

n an anthelmintic agent that acts against the roundworm
Ascaris lumbricoides and the pinworm
Enterobius vermicularis by interfering with their nerve transmissions, thereby causing paralysis.

piperazine

an anthelmintic; several of its salts are used, especially in horses and dogs. A useful agent especially against ascarids. Combined with a benzimidazole is effective against Parascaris equorum and benzimidazole-resistant small strongyles.
Piperazine is a very safe medicament but poisoning occurs on doses that are several times normal. Signs include incoordination, pupillary dilatation, hyperesthesia, somnolence, tremor, swaying at rest and recumbency. Spontaneous recovery usual.
References in periodicals archive ?
Maarseveena, Synthesis of 2-Substituted Piperazines Via Direct a- Lithiation, Tetrahedron Lett.
The S- and N,S-substituted trichlorobutadienes could be obtained from the reactions of polyhalonitrobutadienes We have prepared N,S-substituted trichlorobutadienes from the reaction of some S-substituted nitrobutadienes with piperazine derivatives [4-9].
The piperazine protons of the substituted compounds 5c, 7c, 9c, 11a and 13c have been observed as multiplets around 3.
We saw that the peaks of piperazine methylene groups were broad signals at d = 3.
4 ppm (for the compounds 5d, 7a-b, 9b-c, 11a and 13b-c) for the methylene carbon atom signals of the piperazine ring.
Several piperazine derivatives revealed pronounced medicinal value as antibacterial, antifungal and antitumor agents.
The crude product followed by its reaction with p-anisidine, without isolation treatment,can be carried out in one pot to obtain 1-(4-methoxyphenyl) piperazine in order to avoid purification carcinogenic bis(2-chloroethyl)amine.
1-(4-methoxyphenyl)-4-(nitrophenyl) piperazine is then converted to the desired antifungal intermediate via demethylation.