Immunohistochemistry testing reveals Pick bodies that are tau, RD3, p62, and ubiquitin immunoreactive and RD4, [alpha]-synuclein, and TDP43 negative (Figure 1, a and b).
These corticobasal bodies can be stained with Gallyas, are tau-4R immunoreactive, and are found mostly in the frontal and parietal cortex, in contrast to Pick bodies in Pick disease.
We didn't want to pick bodies
out of that bay," Furno says.
Pathologic findings in neurodegenerative disorders Important Useful pathologic immunohistochemical Disorder findings stains Alzheimer disease Senile plaques and Ass protein, tau, neurofibrillary ubiquitin tangles Frontotemporal lobar degeneration (FTLD): Pick disease Pick bodies
Tau FTLD with TDP43 Motor neuron TDP43, ubiquitin and ubiquitin disease inclusions inclusions FTLD with parkinsonism Neurofibrillary Tau, ubiquitin linked to tangles chromosome 17-tau Corticobasal Ballooned neurons, Tau degeneration tufted astrocytes, coiled bodies Progressive Globose Tau, ubiquitin supranuclear neurofibrillary palsy tangles Dementia with Cortical Lewy [alpha]- Lewy bodies bodies synuclein, ubiquitin Table 2.
Microscopic examination of H&E sections revealed numerous round, discrete, bluegray cytoplasmic inclusions in the hippocampal dentate gyrus approximately the size of dentate gyrus neuronal nuclei, compatible with Pick bodies
(Figure 10, B).