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Diagnosis is tentatively made on the basis of the symptoms presented and their progression over a period of time. Confirmation of the diagnosis of Alzheimer's disease can be made only by postmortem examination of brain tissue. The defining characteristics noted on autopsy are neurofibrillary tangles in the cytoplasm of neurons, neuritic plaques or deposits resulting from degeneration in the neural processes, and granulovacuolar degeneration in the neurons.
Perseveration, or continuous repetition of words or gestures, is characteristic of Alzheimer's disease in its later stages. Personality changes, incontinence, voracious appetite, and a compulsion to put everything in the mouth are other manifestations of the disease.
Family members and other caregivers encounter emotional outbursts and progressive intellectual and physical deterioration that make the tasks of care even more challenging. Part-time or full-time help in the home usually is needed to give some respite to caregivers. They will also need guidance in the management of incontinence and help in coping with role reversals and their own feelings about the loss they have suffered and the burden of care that they bear. Eventually, it may be necessary to institutionalize the person with Alzheimer's disease. This can bring on feelings of guilt and a sense of failure on the part of the caregiver.
Educational materials and information on clinical trials are available from the Alzheimer's Disease Education and Referral Center (ADEAR) by writing them at P.O. Box 8250, Silver Spring MD 20807-8250, calling them at 1-800-272-3900, or consulting their web site at http://www.alzheimer.org.
Pick's disease 1(pĭks) or
Pick's disease 2(pĭks)
Pick's diseaseAphasia-agnosia-apraxia syndrome, Arnold Pick disease, Circumscribed brain atrophy, Lobar sclerosis Neurology A form of dementia characterized by a slowly progressive deterioration of social skills and changes in personality leading to impairment of intellect, memory, and language. See Presenile dementia. Cf Alzheimer's disease.
Pick's diseaseChronic constrictive PERICARDITIS. (Friedel Pick, 1867–1926, Polish ENT specialist).
Patient discussion about Pick's disease
Q. Can a low back pain start from picking up something from the oven? My mother has a low back pain. It started five days ago while she picked up a cake from the oven. the pain is always there, it bugs her while she sleeps and it excruciate while she is doing her regular physical activity. What can it be? should we go to our GP? Is there anything we can do to ease the pain except Tylenol? Just for the record my mom is 69 years old, and she has tuberculosis and a heart disease.
Q. I have a low back pain that radiates to my leg when i pick up stuff. Is it a disc herniation? I am a 43 years old bank teller. During the past 5 months I've suffered from a low back pain. The pain is not very strong, but it gets much worse while doing physical activity. When i walk or lift heavy things the pain is even stronger, and it radiates to my left leg. Can it be signs for disc herniation?
90% or more of herniated discs resolve without surgical treatment within 6 months. MRI imaging is generally only indicated if one is considering surgery; in other words, your pain and neurological status is such that surgery is clinically indicated. Then, an MRI may be helpful for the surgeon. If surgery is not indicated based on clinical/symptoms, then it probably is unwise to get an MRI. They often show abnormalities that are simply 'red herrings' and often prompt people to proceed with surgery that really is not needed. Beware!