PiZZ


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PiZZ

The most common variant allele in α1-antitrypsin deficiency; the common normal allele is PiMM. See α1-antitrypsin deficiency.
References in periodicals archive ?
The presumed incidence of AAT deficiency (e.g., phenotype PiZZ) has been estimated by others (Cox et al.
Patient 2 was homozygous for a glutamate-to-lysine substitution at amino acid 342 in [[alpha].sub.1]-antitrypsin, leading to a charged amino acid substitution (PIZZ).
First, the list of expressions created can now be reordered-although the display is not designed for over 100 of them--which allows, for example, tempo indications to be grouped separately from performance method indications (such as arco and pizz.).
According to the company, the study consists of two parts: Part A in healthy volunteers, which has been completed, and Part B to be conducted in patients with PiZZ genotype AATD.
Homozygous PiZZ is also associated with liver involvement and confers a risk for liver disease, but only a minority of people with this genotype develop cholestasis and/or cirrhosis (2, 4, 5).
As in the Hamelle publication of the church version, the size of the page is practical for performance but the music typeface is much too small--certain indications (pizz., con sourd., dolce) as well as the measure numbers at the top of each page are very tiny indeed.
The company's study consists of two parts: Part A in healthy volunteers, which has been completed; and Part B to be conducted in patients with PiZZ genotype AATD.
Other quibbles with the general layout of these scores concern the use of roman type for virtually every word and marking: vocal texts (of course), dynamics, tempo and expression markings, and all kinds of performance indications (con sord., pizz., etc.).