However, as noted in the Physicians' Desk Reference
(5, 6), changes in peroxisome morphology and numbers have been observed in humans after treatment with several members of the fibrate class, including clofibrate, when liver biopsies were compared before and after treatment in the same individual.
A few years ago, he noticed something odd while looking up information on lovastatin (Mevacor), a popular cholesterol-lowering drug, in the Physicians' Desk Reference
(PDR) , a directory of federally approved prescription drugs.
The Physicians' Desk Reference
(PDR) write-up for prescription Tagamet, which is the same as the FDA-approved package insert, runs nine columns in small type.
Similarly, online medical reference works such as the "Physicians' Desk Reference
" or the "Scientific American Medicine Textbook of Medicine," are becoming instantly available in the form of vendor-supported electronic databases that can be purchased by a healthcare enterprise in support of its healthcare workers.
Additional CD-ROM health care reference products, including The Family Doctor (Creative Multimedia Corporation), PDR (Physicians' Desk Reference
) with the Merck Manual (Medical Economics Data), and Scientific American Medicine (Scientific American Medicine) have been reviewed by LaGuardia (1993).
(8) Although the drug has returned to the Canadian market and a clear link between stroke or sudden death and Adderall has not been established, The Physicians' Desk Reference
(PDR) (9) advises physicians to monitor blood pressure in individuals taking amphetamine/dextroamphetamine, particularly those with hypertension.
Fourteen percent had hypertriglyceridemia at baseline; this rate jumped to 50% during isotretinoin therapy These real-world data were surprising; the Physicians' Desk Reference
(PDR) describes the hypertriglyceridemia rate in the isotretinoin clinical trials as 25%.
Warfarin is listed in the Physicians' Desk Reference
as contraindicated in pregnancy.
The vestigial library now consists of current copies of the Red Book and the Physicians' Desk Reference
, along with a 1969 edition of "Nelson's Pediatrics."
Source: FDA Orange Book, IMS Health, Physicians' Desk Reference