Nanomaterials can be utilized as passive carriers of photosensitizers
[89, 90] to increase therapeutic concentration accumulated in tumor area while minimizing the collateral toxicity to nonmalignant cells.
The autosensitized photooxidation reaction is harmful to photodynamic interaction because it destroys the large-ring molecule structure of the photosensitizer
and causes quick consumption of the oxygen species.
New Amphiphilic Silicon(iv) Phthalocyanines as Efficient Photosensitizers
for Photodynamic Therapy: Synthesis, Photophysical Properties, and in vitro Photodynamic Activities.
12) The use of photoactivatable compounds or photosensitizers
(PS) to cause photodestruction of oral bacteria has been demonstrated, indicating that photodynamic therapy (PDT) could be a useful alternative to mechanical means as well as antibiotics in eliminating periopathogenic bacteria.
Photodynamic therapy (PDT) involves the activation of a photosensitizer
with light of the appropriate wavelength to produce reactive oxygen species, including singlet oxygen, which produces focal damage to tissue, e.
used in PDT must have certain properties.
It has been shown that excitation transfer occurs in a mixture of a morpholino ketone TMPK and a thioxanthone derivative TX where TMPK and TX play the role of a photoinitiator I and a photosensitizer
S respectively (Scheme 1).
9-11) The mechanism of action involves fungal absorption of a chemical, which is metabolized into a photosensitizer
, followed by exposure to a specific wavelength light that results in subsequent reactive oxygen species and fungal death.
The type of molucules that can act as photosensitizers
in biological systems is very large.
When the photosensitizers
are activated by the laser light, they produce a form of oxygen that destroys illuminated cancer cells.
Objective: This proposed Fellowship brings together an Experienced Researcher from India with expertise in the synthesis of photosensitizers
and their photophysical characterization, tuning the excited-state properties, investigation of their photophysics and photobiology with an internationally recognized Host Laboratory in France with expertise in designing fluorescent molecular and nanoparticle probes for bioimaging.
2) studied the production of singlet oxygen of the substituted photosensitizers
difurnonaphthalene and distyryl benzene.