photosensitizer

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photosensitizer

Oncology A substance that sensitizes an organism, cell, or tissue to light; an agent used in photodynamic therapy which, when absorbed by CA cells and exposed to light, is activated, killing cancer cells. See Photodynamic therapy.

photosensitizer

(fō″tō-sĕn′sĭ-tī″zĕr)
A substance that, in combination with light, will cause a sensitivity reaction in the substance or organism.
References in periodicals archive ?
The light dose delivered determines the size of the PDT lesion, so that larger tumour masses can be treated using multiple laser fibres or with sequential fibre placement within a treatment window of 15 minutes to 1 hour after injection of photosensitiser. Waiting for longer periods of up to 4 hours, as shown in Figure 2, to allow talaporfin to distribute into the extracellular matrix, did not seem advantageous in this study, as fluorescence data showed no increase in talaporfin tissue levels than earlier time periods and PDT lesions seen in the liver were smaller than at 15 minutes.
The wavelength of light absorption is specific for each photosensitiser. For instance, malachite green, rose bengal and methylene blue absorb in solar UV-A region wavelength at A max = 380 nm.
We propose the effective fluorescence g-factor to be a parameter as it can show the depth of fluorescent photons propagation after their emission due to excitation of a photosensitiser contained in the tissue.
The PCI method involves first injecting target cells with a photosensitiser. Therapeutic molecules are then delivered to the cells and when these are illuminated the cells' endosomes are ruptured to allow successful uptake.
19 October 2009 - Norwegian company PCI Biotech Holding ASA (OSL: PCIB) announced today the completion of treatment of the first dose group in the phase I/II study of its proprietary photosensitiser Amphinex in cancer patients.
Researchers are using photosensitisers that contain metal nanoparticles to target the MRSA, which kills hundreds of patients in Britain every year.
Wainwright, Photosensitisers in Biomedicine, John Wiley & Sons, Ltd, Chichester, UK, 2009.
Giddens, "Phenothiazinium photosensitisers: choices in synthesis and application," Dyes and Pigments, vol.
photonamic GmbH and Co KG was established in 2003 to develop photosensitisers in the field of fluorescence guided diagnostics and photodynamic therapy.
Photodynamic therapy: the development of new photosensitisers. Anticancer Agents Med Chem.
The retina is particularly susceptible to oxidative stress due to its high oxygen utilisation, the presence of photosensitisers such as rhodopsin and exposure to intense light conditions.