phosphoribosyltransferase


Also found in: Acronyms.

phos·pho·ri·bo·syl·trans·fer·ase

(fos'fō-rī'bō-sil-trans'fĕr-ās),
One of a group of enzymes (EC 2.4.2.x, pentosyltransferases) that transfers d-ribose 5-phosphate from 5-phospho-α-d-ribosyl pyrophosphate to a purine, pyrimidine, or pyridine acceptor, forming a 5'-nucleotide and pyrophosphate, or d-ribose from d-ribosyl phosphate to a base, forming a nucleoside, or similar pentose transfers; important in nucleotide biosynthesis. Specific phosphoribosyltransferases are preceded by the name of the acceptor base, for example, uracil phosphoribosyltransferase (that is, uracil + PRPP ⇋ UMP + pyrophosphate).

phosphoribosyltransferase

(fŏs″fō-rī″bō-sĭl-trăns′fĕr-ās)
An enzyme that catalyzes reconversion to the ribonucleotide stage of the purine bases, hypoxanthine and guanine. The deficiency of this enzyme is inherited as an X-linked trait.
References in periodicals archive ?
Epidemiology of Adenine Phosphoribosyltransferase Deficiency
2009) Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes.
The gene HPRT is named for the enzyme it encodes, hypoxanthine-guanine phosphoribosyltransferase.
A series of follow up experiments performed by Gemin X scientists convincingly validated this finding and further narrowed down the target to be nicotinamide phosphoribosyltransferase (NAMPT), a key regulatory enzyme in NAD biosynthesis.
In the present studies, hypoxanthine phosphoribosyltransferase (HPRT) was chosen as the reference gene both for adipose and liver tissue.
In leukemia cells, the phosphorylation of EIF2S1 also inhibits the activities of nicotinamide phosphoribosyltransferase (NAMPT), a factor known to regulate cancer cell metabolism [20].
For the overexpression of NAD synthesizing enzyme nicotinamide phosphoribosyltransferase (NAMPT) was reported to protect the heart against I/R injury, significantly decreasing the infarct size and apoptosis [37].
To evaluate whether an increased postmortem period affects capability of the isolated RNA to serve as the template in gene expression studies, qPCR of five common reference genes (ACTB, GAPDH, hypoxanthine-guanine phosphoribosyltransferase [HPRT], peptidylprolylisomerase A; PPIA, TATA box-binding protein [TBP]) and three selected genes, including insulin-like growth factor (IGF1), pyruvate dehydrogenase kinase, isozyme 4 (PDK4) and peroxisome proliferator-activated receptor delta (PPARD), which were associated with meat quality (Malila et al.
examined the effect of high glucose on the genomic stability of phosphoribosyltransferase and thymidine kinase loci in human lymphoblastoid cell lines and reported a significant increase in mutations in both loci under high glucose.
Amplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases.
Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene.