phosphoinositide

phos·pha·ti·dyl·in·o·si·tol (PtdIns),

(fos'fă-tī'dĭl-in-ō'si-tol),
A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide.
Synonym(s): phosphoinositide
References in periodicals archive ?
The product is an oral inhibitor of phosphoinositide 3-kinase and the first approved dual inhibitor of PI3K-delta and PI3K-gamma.
M2 PRESSWIRE-July 29, 2019-: Global Phosphoinositide 3-Kinase (PI3K) Inhibitors Market Outlook 2019-2023 with Bayer, Gilead Sciences, Novartis, TG Therapeutics, and Verastem Leading the Competition
Verastem Oncology's COPIKTRA is an oral inhibitor of phosphoinositide 3-kinase (PI3K) and the first approved dual inhibitor of PI3K-delta and PI3K-gamma.
However, unlike [MT.sub.1] receptors, [MT.sub.2] receptors have been indicated to cause phosphoinositide hydrolysis (9).
Phosphoinositide 3-kinase (PI3K) inhibitor LY294002 was utilized to probe whether the PI3K signaling pathway was involved in LXA4 induction of candidate gene expression.
10, 2018 (HealthDay News) -- For patients with relapsed or refractory (RR) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), the oral, dual inhibitor of phosphoinositide 3-kinase-?
LIF has a critical role as a survival factor in several cell types during in vitro culture, acting via phosphoinositide 3-kinase pathways (12, 13).
Petra is a pharmaceutical company dedicated to discovering and developing novel therapies that modulate phosphoinositide (PI) signaling pathways for the treatment of cancer and other serious diseases.
Nakamura, "Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance," Progress in Lipid Research, vol.
Owing to their phox phosphoinositide binding domain, members of this family are involved in intracellular trafficking.
Additionally, apelin binding APJ activated phosphorylation of phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), which play an important role in cell proliferation or apoptosis.

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