autocrine motility factor

(redirected from Phosphoglucose isomerase)
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autocrine motility factor

A multifunctional cytokine protein capable of affecting cell migration, invasion, proliferation and survival, which possesses phosphoglucose isomerase activity and can catalyse glycolysis and gluconeogenesis. AMF is secreted by tumours and is abundant in sites of malignany, where it may affect tumour growth and metastasis. Both activities are inhibited by pertussis toxin, implying that AMF acts by a guanine nucleotide-binding protein (G-protein pathway); a 78-kD glycoprotein acts as an AMF receptor on melanomas and may have a role in melanocyte locomotion.

autocrine motility factor

A chemical released by cancer cells that induces motility, enabling the cells to metastasize.
See also: factor
References in periodicals archive ?
For the assessment of metabolic capacities and their effects on the reproductive cycle, we measured the glycolytic enzymes phosphoglucose isomerase (PGI), phosphomannose isomerase (PMI), pyruvate kinase (PK), one enzyme of protein metabolism (aspartate aminotransferase [AAT]), and the mitochondrial enzyme citrate synthase (CS) in the adductor muscle of scallops P.
Phosphoglucose isomerase (PGI), phosphoglucomutase (PGM), glutamate oxaloacetate transaminase (GOT), triosphosphate isomerase (TPI), anodal peroxidase (PRX), esterase (EST), and alcohol dehydrogenase (ADH) were resolved in Tris-citrate/lithium-borate pH 8.
2 = alanine aminotransferase), and phosphoglucose isomerase (Pgi, EC 5.
Intramolecular hydrogen transfer in the phosphoglucose isomerase reaction.
The adaptive significance of electrophoretic mobility in phosphoglucose isomerase (PGI).
Yamamoto and Duich (1994) were able to identify 12 of 12 synthetic creeping bentgrass cultivars based on phosphoglucose isomerase banding patterns.
1986)]: acid phosphatase (ACP), alanine dehydrogenase (ALA), butyrate esterase (EST), [Beta]-hydroxybutyrate dehydrogenase (HBD), diaphorase (DIA), fumarase (FUM), fructose-1,6-diphosphatase (F16), glucose-6-phosphate dehydrogenase (G-6), glutamic-oxalacetic transaminase (GOT), glyceraldehyde-3-phosphate dehydrogenase type 1 (GP1), isocitrate dehydrogenase (IDH), indophenol oxidase (IPO), leucine aminopeptidase (LAP), leucine tyrosine peptidase (PEP), malate dehydrogenase (MDH), malic enzyme (ME), phosphoglucose isomerase (PGI), phosphoglucomutase (PGM), 6-phosphogluconate dehydrogenase (6PGD), and shikimate dehydrogenase (SDH).
The 13 enzyme systems (and 18 associated, polymorphic loci) assayed for this study were acid phosphatase (Acp), diaphorase (Dia2), fluorescent esterase (Fe2, Fe3), glutamate oxaloacetate transaminase (Got1, Got2), isocitrate dehydrogenase (Idh), leucine aminopeptidase (Lap1, Lap2), malate dehydrogenase (Mdh), malic enzyme (Me), 6-phosphogluconate de hydrogenase (6Pgd1, 6Pgd2), phosphoglucose isomerase (Pgi2), phosphoglucomutase (Pgm1, Pgm2), shikimate dehydrogenase (Skdh), and triosphosphate isomerase (Tpi1).
Polymorphic loci were identified for the following enzymes: Aconitase (ACO), esterase (EST), malate dehydrogenase (MDH) (two loci), 6-phosphogluconate dehydrogenase (PGD), phosphoglucose isomerase (PGI), and phosphoglucomutase (PGM).
1980) was used to resolve phosphoglucose isomerase (Pgi-2), menadione reductase (Mnr-1), and triosephosphate isomerase (Tpi-2).
These enzymes included alanine transferase (Alt-2); fluorescent esterase (Fle-2); glutamate oxaloacetate transaminase (Got-1, Got-2); glutamate dehydrogenase (Gdh-1); isocitrate dehydrogenase (Idh-1); leucine aminopeptidase (Lap-1); malate dehydrogenase (Mdh-1, Mdh-2); menadione reductase (Mnr-1, Mnr-2); phosphoglucomutase (Pgm-1); 6-phosphogluconate dehydrogenase (Pgd-1); phosphoglucose isomerase (Pgi-2); and triosephosphate isomerase (Tpi-1, Tpi-2).

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