phosphodiester bond

(redirected from Phosphoester)
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phosphodiester bond

(fŏs′fō-dī-ĕs′tər)
n.
A covalent chemical bond that links two carbon atoms through a phosphate group, especially the bonds that link the pentose sugars of adjacent nucleotides in polynucleotide chains of RNA and DNA.

phosphodiester bond

The chemical linkages that join up the sugar, base and phosphate NUCLEOTIDES of DNA and RNA into polynucleotide strands. The subunits of the strand are triphosphate nucleosides, but when a number of these join up (polymerize) under the action of the enzyme DNA polymerase, two of the phosphates are cleaved off leaving only one phosphorous atom between each pair of adjacent sugar molecules. The two ester (diester) bonds in each linkage are Carbon-Oxygen-Phosphorus from the 5’-carbon on one sugar and Carbon-Oxygen-Phosphorus from the 3’-carbon on the next. The hydroxyl (-OH) on the 3’-carbon is also lost.

phosphodiester bond

a bond between a sugar group and a phosphate group. In NUCLEIC ACIDS the NUCLEOTIDES are covalently linked by phosphodiester bonds between the phosphate and the 3′ and 5′ hydroxyls of adjacent sugars resulting in an alternating sugar-phosphate backbone:

References in periodicals archive ?
In addition to ionization conditions, the matrix used in MALDI may play a role in the stability of phosphoester linkage and its mass analysis.
Peripheral nerve regeneration with sustained release of poly (phosphoester) microencapsulated nerve growth factor within nerve guide conduits.
Because of the greater stability of a phosphodiester linkage, as used in the C3 linker, relative to a single phosphoester bond, it appears that all of these concerns can be alleviated by replacing the phosphate cap with an alkyl group via common phosphoramidite chemistries.
AR antagonist activity decreased as alkyl chain length of the phosphoester increased, whereas electron-donating properties of phenyl substituents of the tested compounds did not influence AR activity.
DMAE has also been incorporated in a nutraceutical formulation which also includes phosphoesters and antioxidants.
Gilbert; "Evaluation of poly (phosphoesters) or degradable biomaterials," K.W.

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