The incisions were performed at four precise locations relative the UV adduct, one at the 8th phosphodiester
bond 5' to the lesion and a second at the 4th or 5th bond 3' to the same lesion, thus generating a 12-13 nt long fragment.
All living systems contain nucleases, capable of interacting with nucleic acids and hydrolyzing the phosphodiester
1241###-###P=O of phosphodiester
group of nucleic acids and phospholipids
CdtB exhibits DNase I activity, disrupting the phosphodiester
bonds in chromosomal DNA.
Each nucleotide connects to another one with phosphodiester
bonds of ATP contain the energy necessary to drive reactions in living systems, giving up their stored energy when these bonds are chemically cleaved.
The hydrolysis of the phosphodiester
bond drastically affects the toxicity of organophosphate pesticides, thus being an important step for their detoxification [4, 5].
PNA has the same nucleotide bases (A, T, C and G) but having peptide backbone instead of phosphodiester
The individual nucleotides are joined together by groups of phosphates that form the phosphodiester
bond between the 3' and 5' carbon atoms of sugars.
This site is also characterized by the moiety DRGH, histidine (H) being responsible for the activation of the water molecule needed to carry out hydrolysis of the phosphodiester
Separating DNA strands: The hydrogen bonding between the complementary bases is weaker than the phosphodiester
bond between consecutive nucleotides within a strand.
Zagorowska, I, Kuusela, S, Lonnberg, H, "Metal Ion-Dependent Hydrolysis of RNA Phosphodiester
Bonds Within Hairpin Loops.