(redirected from Phosphatidylinositide)

phos·pha·ti·dyl·in·o·si·tol (PtdIns),

A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide.
Synonym(s): phosphoinositide
References in periodicals archive ?
The Company initiated a first-in-human clinical study of PWT143, a highly selective oral inhibitor of phosphatidylinositide 3-kinase (PI3K) delta, in healthy subjects in June 2015.
Abbreviations: NF-[kappa]B, nuclear factor-kappaB; mapk, mitogen-activated protein kinase; P13K, phosphatidylinositide 3-kinase: Akt, protein kinase B; FAK, focal adhesion kinase; PSG, prostate-specific G-protein-coupled receptor; IL-6, interleukin-6; JNK, c-Jun NH(2)-terminal kinase; TLC, thin layer chromatography; NMR, nuclear magnetic resonance; FBS, fetal bovine serum; DCC, dextran coated charcoal slurry; RT, room temperature; GC-MS, gas chromatography-mass spectrometry; MIC, minimum inhibitory concentration; AIDS, acquired immunodeficiency syndrome; PI, propidium iodide; RI, retention indices; AP-1, activator protein 1; CREB, cAMP response element-binding protein; c/EBP, CCAAT/enhancer binding protein; SAPK, stress-activated protein kinases.
inhibitors of Phosphatidylinositide 3-kinases (PI3K).
Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase-dependent clonogenic response in acute myeloid leukemia cells.
The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophrenia.
Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin.
D-Mannose is an essential monosaccharide in the structure of glycoproteins, cell-surface glycoconjugates, and glycosylated phosphatidylinositide anchors.
In pre-clinical studies, PWT143 has been found to be a potent and highly selective oral inhibitor of phosphatidylinositide 3-kinase (PI3K) delta, a molecular target that has been shown to play a critical role in the proliferation and survival of hematologic cancer cells.
Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide.

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