phosphatidic acid

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phos·pha·tid·ic ac·id

(fos'fă-tid'ik as'id),
1,2-Diacylglycerol phosphate; a derivative of glycerophosphoric acid in which the two remaining hydroxyl groups of the glycerol are esterified with fatty acids; for example, phosphatidic acids attached to choline are phosphatidylcholines (lecithins).

phosphatidic acid

/phos·pha·ti·dic ac·id/ (-tid´ik) any of a group of compounds formed by esterification of three hydroxyl groups of glycerol with two fatty acid groups and one phosphoric acid group; from it are derived the phosphoglycerides.

phosphatidic acid

a precursor of triacylglycerols and some phospholipids. Its biologically important derivatives include cardiolipin and compounds consisting of a phosphate ester linked to ethanolamine, inositol, serine or choline, i.e. phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine.
References in periodicals archive ?
Researchers showed that lipid molecules called phosphatidic acids enhance glucose production in the liver.
is a privately held, Seattle-based pharmaceutical company focused on discovery, development and commercialization of small molecule drugs that modulate the production of cell membrane lipids called phosphatidic acids for the treatment of cancer and inflammatory and immune diseases.
Cti focuses on the discovery, development and commercialization of small molecule drugs that modulate the production of cell membrane lipids called phosphatidic acids for the treatment of cancer, inflammatory and immune diseases.
Cell Therapeutics' investigation into lisofylline's ability to prevent or treat these severe inflammation conditions in which normal tissues are damaged, resulting in organ dysfunction or damage, developed from the Company's discovery that certain cell membrane lipids, called phosphatidic acids (PAs), may constitute a unique intracellular, second messenger pathway (named the Bursten Pathway, after one of the scientific founders of the Company) that appears to be activated only in response to stressful, potentially cell-damaging or cell-threatening stimuli, and not utilized in normal cellular processes.
on a phosphatidic acid pathway that appears to be specific to all