PTEN

(redirected from Phosphatase and Tensin Homolog)
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PTEN

A gene on chromosome 10q23.3 which encodes PTEN (phosphatase and tensin homolog), a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase protein, which acts as a tumour suppressor by negatively regulating the AKT/PKB-signalling pathway.
References in periodicals archive ?
Expression levels of AT-rich interactive domain-containing protein 1A (ARID1A) and phosphatase and tensin homolog (PTEN) proteins in mouse ovaries.
Serum AT-rich interactive domain-containing protein 1A (ARID1A) (A) and phosphatase and tensin homolog (PTEN) (B) concentrations after different concentrations of FSH receptor binding inhibitor (FRBI-10 to -40).
Indexes FRBI dose TP ARID1A PTEN TP -0.758 ARID1A 0.944 * -0.928 * PTEN 0.934 * -0.571 0.829 FSHRm -0.993 ** 0.827 -0.976 ** -0.911 * FSHRp -0.937 * 0.501 -0.788 -0.984 ** p-FSHR 0.881 * -0.457 0.742 0.966 ** IP3 -0.438 -0.105 -0.172 -0.415 Indexes FSHRm FSHRp p-FSHR TP ARID1A PTEN FSHRm FSHRp 0.898 * p-FSHR -0.848 -0.968 ** IP3 0.341 0.553 -0.395 FRBI: FSH receptor binding inhibitor; TP: total proteins in ovarian tissue; ARID1A: AT-rich interactive domain-containing protein 1A; PTEN: phosphatase and tensin homolog; FSHRm: follicle-stimulating hormone cognate receptor mRNAs; FSHRp: FSHR proteins; p-FSHR: ovarian phosphorylated-FSHR; IP3: inositol trisphosphate.
Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
Loss of phosphatase and tensin homolog protein expression is an independent poor prognostic marker in lung adenocarcinoma.
Bioinformatics analysis showed that phosphatase and tensin homolog deleted on chromosome 10 (PTEN), commonly known as a tumor suppressor gene which encodes a phosphoinositide phosphatase that opposes the phosphatidylinositol 3-kinase (PI3K)-Akt pathway,[sup][11],[12] is a candidate target of miR-106b-5p.
Phosphatase and tensin homolog deleted on chromosome 10 is a direct target of miR-106b-5p
Kaplan-Meier curves for disease-free survival (A) and overall survival (B) by phosphatase and tensin homolog (PTEN) expression levels in patients with ampullary adenocarcinoma after curative surgery.
Phosphatase and tensin homolog (PTEN), which is located at chromosome 10q23.3, spans 105 kb and includes 9 exons and 8 introns.
Phosphatase and tensin homolog SNPs in the promoter, intronic, intron/exon boundary, exonic and 3'UTR regions were initially screened using the International HapMap Project tag SNP information in the Han Chinese population (http://hapmap.ncbi.nlm.nih.gov/).
Associations of phosphatase and tensin homolog single nucleotide polymorphisms with the risk of hepatocellular carcinoma
[3] Nonstandard abbreviations: NS, nephrotic syndrome; MCD, minimal-change disease; FSGS, focal segmental glomerulosclerosis; CD2AP, CD2-associated protein; miRNA, microRNA; antagomiR, miRNA antagonist; PTEN, phosphatase and tensin homolog.