PTEN

(redirected from Phosphatase and Tensin Homolog)
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PTEN

A gene on chromosome 10q23.3 which encodes PTEN (phosphatase and tensin homolog), a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase protein, which acts as a tumour suppressor by negatively regulating the AKT/PKB-signalling pathway.
References in periodicals archive ?
Kaplan-Meier curves for disease-free survival (A) and overall survival (B) by phosphatase and tensin homolog (PTEN) expression levels in patients with ampullary adenocarcinoma after curative surgery.
3] Nonstandard abbreviations: NS, nephrotic syndrome; MCD, minimal-change disease; FSGS, focal segmental glomerulosclerosis; CD2AP, CD2-associated protein; miRNA, microRNA; antagomiR, miRNA antagonist; PTEN, phosphatase and tensin homolog.
Many prostate cancer patients display mutations in the phosphatase and tensin homolog (PTEN) gene.