(redirected from Phosphatase and Tensin Homolog) Also found in: Acronyms.
A gene on chromosome 10q23.3 which encodes PTEN (phosphatase and tensin homolog), a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase protein, which acts as a tumour suppressor by negatively regulating the AKT/PKB-signalling pathway.
Expression levels of AT-rich interactive domain-containing protein 1A (ARID1A) and phosphatase and tensin homolog (PTEN) proteins in mouse ovaries.
Serum AT-rich interactive domain-containing protein 1A (ARID1A) (A) and phosphatase and tensin homolog (PTEN) (B) concentrations after different concentrations of FSH receptor binding inhibitor (FRBI-10 to -40).
Bioinformatics analysis showed that phosphatase and tensin homolog deleted on chromosome 10 (PTEN), commonly known as a tumor suppressor gene which encodes a phosphoinositide phosphatase that opposes the phosphatidylinositol 3-kinase (PI3K)-Akt pathway,[sup], is a candidate target of miR-106b-5p.
Phosphatase and tensin homolog deleted on chromosome 10 is a direct target of miR-106b-5p
Phosphatase and tensin homolog (PTEN), which is located at chromosome 10q23.3, spans 105 kb and includes 9 exons and 8 introns.
Phosphatase and tensin homolog SNPs in the promoter, intronic, intron/exon boundary, exonic and 3'UTR regions were initially screened using the International HapMap Project tag SNP information in the Han Chinese population (http://hapmap.ncbi.nlm.nih.gov/).
Associations of phosphatase and tensin homolog single nucleotide polymorphisms with the risk of hepatocellular carcinoma