PTEN

(redirected from Phosphatase and Tensin Homolog)
Also found in: Acronyms.

PTEN

A gene on chromosome 10q23.3 which encodes PTEN (phosphatase and tensin homolog), a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase protein, which acts as a tumour suppressor by negatively regulating the AKT/PKB-signalling pathway.
References in periodicals archive ?
Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
Loss of phosphatase and tensin homolog protein expression is an independent poor prognostic marker in lung adenocarcinoma.
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Kaplan-Meier curves for disease-free survival (A) and overall survival (B) by phosphatase and tensin homolog (PTEN) expression levels in patients with ampullary adenocarcinoma after curative surgery.
03 Yes 19 Abbreviations: AJCC, American Joint Committee on Cancer; PTEN, phosphatase and tensin homolog.
Overexpression of miR-106b-5p inhibits phosphatase and tensin homolog deleted on chromosome 10 expression in human umbilical vein endothelial cell
Phosphatase and tensin homolog (PTEN), which is located at chromosome 10q23.
Phosphatase and tensin homolog SNPs in the promoter, intronic, intron/exon boundary, exonic and 3'UTR regions were initially screened using the International HapMap Project tag SNP information in the Han Chinese population (http://hapmap.
3] Nonstandard abbreviations: NS, nephrotic syndrome; MCD, minimal-change disease; FSGS, focal segmental glomerulosclerosis; CD2AP, CD2-associated protein; miRNA, microRNA; antagomiR, miRNA antagonist; PTEN, phosphatase and tensin homolog.