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The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of phorbol found in croton oil; the hydrocarbon skeleton is a cyclopropabenzazulene; phorbol esters mimic 1,2-diacylglycerol as activators of protein kinase C.
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References in periodicals archive ?
3) competes for the same binding site as phorbol esters on mammalian protein kinase C (PKC) (Wender et al., 1988; Kazanietz et al., 1994).
The phorbol ester receptor: a phospholipid-regulated kinase.
Demonstration of sub-nanomolar affinity of bryostatin I for the phorbol ester receptor in rat brain.
Application of a radioreceptor assay to the screening and characterization of compounds from marine organisms with activity at the phorbol ester binding site of protein kinase C.
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.