phorbol

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phor·bol

(fōr'bol),

The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of phorbol found in croton oil; the hydrocarbon skeleton is a cyclopropabenzazulene; phorbol esters mimic 1,2-diacylglycerol as activators of protein kinase C.

phorbol

/phor·bol/ (for´bol) a polycyclic alcohol occurring in croton oil; it is the parent compound of the phorbol esters.

phorbol ester any of several esters of phorbol that are potent cocarcinogens, activating a cellular protein kinase; used in research to enhance the induction of mutagenesis or tumors by carcinogens.

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References in periodicals archive ?

The capability of bryostatins to displace phorbols irreversibly (de Vries et al.

The phorbol ester receptor: a phospholipid-regulated kinase.

Demonstration of sub-nanomolar affinity of bryostatin I for the phorbol ester receptor in rat brain.

Application of a radioreceptor assay to the screening and characterization of compounds from marine organisms with activity at the phorbol ester binding site of protein kinase C.

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.