phorbol

(redirected from Phorbol esters)

phor·bol

(fōr'bol),
The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of phorbol found in croton oil; the hydrocarbon skeleton is a cyclopropabenzazulene; phorbol esters mimic 1,2-diacylglycerol as activators of protein kinase C.

phorbol

/phor·bol/ (for´bol) a polycyclic alcohol occurring in croton oil; it is the parent compound of the phorbol esters.
phorbol ester  any of several esters of phorbol that are potent cocarcinogens, activating a cellular protein kinase; used in research to enhance the induction of mutagenesis or tumors by carcinogens.
References in periodicals archive ?
However, Makkar and Becker [5] reported that the presence of a cocktail of anti-nutritional factors like phorbol esters, saponins, tannins, phytates, lectins, hydrocyanides and oxalates prevent its use in animal feeding; phorbol ester is considered the most toxic compound.
However biological treatments may alleviate the concentration of phorbol esters to a safe level.
It was reported on Tuesday that the contract has been signed for ownership of its investigational cancer patent assignment using Phorbol Esters in the treatment of Hodgkin's Lymphoma.
Jatropha curcas is a non-edible vegetable oil due to the presence of phorbol esters which accounts for its toxicity.
Not content just to cause pain and blindness, the plant has long-term ideas as well: it contains phorbol esters, which are not only skin irritants but actually promote cancer development, suppress the immune system and activate dormant Epstein-Barr virus.
Tumor-promoting phorbol esters induce metamorphosis and multiple head formation in the hydroid Hydractinia.
TPA, a kind of phorbol esters, is one of the main irritant compounds in Euphorbiaceae plants.
v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.
Direct activation of PKC by phorbol esters (PMA) or a PMA analog, phorbol 12, 13 dibutyrate, desensitizes the receptor.
In previous studies, the Johns Hopkins researchers described how the lung's epithelial cells respond to a number of carcinogens and pro-carcinogens-including phorbol esters, retinoic-acid deprivation, and tobacco smoke--by changing into squamous cells.
Once CD69 is expressed in response to submitogenic doses of phorbol esters, the addition of mAbs against CD69 triggers cell proliferation [15].