nefazodone hydrochloride

(redirected from Phenylpiperazine)

nefazodone hydrochloride

(nə-fā′zə-dōn′, -făz′ə-)
n.
An oral antidepressant with a chemical structure unrelated to SSRIs, tricyclics, or monoamine oxidase inhibitors, thought to inhibit neuronal uptake of serotonin and norepinephrine.

nefazodone hydrochloride

[nĕfa′zodōn]
an antidepressant drug.
indication It is prescribed in the treatment of mental depression in adults.
contraindications It should not be given to patients with an allergy to nefazodone hydrochloride or similar antidepressants, patients in the recovery phase of acute myocardial infarction, or patients also using monoamine oxidase inhibitors, pimozide, or carbamazepine. Caution is advised in prescribing it for patients with concurrent use of triazolam or alprazolam, a history of drug abuse, cardiovascular disease, low blood pressure, seizures, benign prostatic hyperplasia, constipation, or suicidal ideation.
adverse effects It has rarely caused life-threatening liver failure, so it should be discontinued immediately if there are signs of hepatic toxicity. The side effects most often reported include dry mouth, impaired vision, eye pain, flulike symptoms, ringing in the ears, swollen limbs, and muscle pain.
References in periodicals archive ?
A model compound, phenylpiperazine, was found to decompose to a N-phenylethylenediamine after sunlight exposure at a much slower rate compared to ciprofloxacin.
Keywords: Ciprofloxacin ophthalmic solution, sunlight, photodegradation, phenylpiperazine, electrospray mass spectrometry
In order to gain insight into the mechanism of this photolytic degradation of the ciprofloxacin molecule, a model compound, phenylpiperazine in aqueous solution (0.
Serzone is contraindicated in patients with known hypersensitivity to nefazodone or other phenylpiperazine antidepressants.
A model compound, phenylpiperazine also was found to decompose in a similar fashion but after a long duration of sunlight exposure compared to ciprofloxacin.