Mallinckrodt acquired MNK-6106 and the intravenous investigational drug MNK-6105 (L-ornithine phenylacetate
) when it completed the acquisition of Ocera Therapeutics in December 2017.
Serum PON1 arylesterase activity was measured with phenylacetate
substrate (Sigma Aldrich, Hungary), and the hydrolysis of phenylacetate
was monitored at 270 nm at room temperature as previously described [30, 31].
is a clinical stage biopharmaceutical company focussed on the development and commercialisation of OCR-002 (ornithine phenylacetate
) in both intravenous and oral formulations.
The supply of generated p-nitrophenol was calculated from the molar absorptive at pH 8 (17,000 M-1 cm-1).11 Phenylacetate
was used as a substrate to evaluate ARES activity.
The carboxylic acid ester phenylacetate
and its analogs have also been linked to breast neoplasms (Sawatsri et al.
subfasciatus in the field, and also showed that traps baited with methyl phenylacetate
Two absorption bands at 1458, 1349 cm-1 were observed due to presence of NO2 substituent on phenylacetate
Machado and Pinheiro da Silva (13) recommend sodium phenylacetate
, sodium benzoate, and sodium phenylbutyrate to provide alternative pathways to eliminate ammonia via renal excretion.
Ammonia scavenger therapy with intravenous sodium benzoate and sodium phenylacetate
Phenylbutyrate does not accumulate in plasma and converted into phenylacetate
which is its active form.
Arylesterase activity was measured by assessing the rate of hydrolysis of phenylacetate
by monitoring the increase of absorbance at 270 nm, after adding 10 [micro]L of serum (diluted 24 times).
Similarly, phenylacetylglycine (PAG), formed by the conjugation of phenylacetyl-CoA with glycine and regarded as a surrogate biomarker for phospholipidosis , correlates with the production of phenylacetate
, which is influenced by the [beta]-oxidation of fatty acids, the metabolic formation of phenylalanine, and gut flora .