phenothiazines

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Related to phenothiazines: Benzodiazepines, chlorpromazine

phenothiazines

(fe?no-thi'a-zenz)

A class of major tranquilizers used to treat psychotic illnesses such as schizophrenia. They have neuroleptic and antiemetic effects. Among the most commonly used agents in this class are chlorpromazine, haloperidol, prochlorperazine, and thioridazine. Side effects of these drugs include dystonic reactions, tardive dyskinesia, seizures, and sedation. See: neuroleptic

phenothiazines

An important group of drugs derived from a molecule with a three-ring structure in which two benzene rings are linked by a sulphur and a nitrogen atom. They are widely used to treat serious mental (psychotic) illness and to relieve severe nausea and vomiting. Phenothiazines are divided into three groups. Group I contains drugs such as chlorpromazine (Largactil), methotrimeprazine (Nozinan) and promazine. Group II includes thioridazine (Melleril), pericyazine (Neulactil) and pipothiazine (Piportil Depot). And group III contains prochlorperazine (Stemetil, Buccastem), perphenazine (Fentazin), fluphenazine (Modicate, Moditem, Motival), trifluoperazine (Stelazine) and amitriptyline (Triptafen).

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

References in periodicals archive ?

Less frequently, cases related to chlorpromazine and rarely to other phenothiazines are reported.

Psychotropic drugs and ocular side effects/Psikotropik ilaclar ve okuler yan etkileri

The use of an antihistamine ([H.sub.1]-receptor antagonist) or a phenothiazine may be limited by sedation, particularly with increasing doses.

The pharmacologic management of nausea and vomiting of pregnancy

Phenothiazine derivatives, such as acepromazine (ACP), are widely used in veterinary medicine with the aim to produce sedation in dogs.

Comparison of the sedative effects of morphine, meperidine or fentanyl, in combination with acepromazine, in dogs/Comapracao dos efeitos sedativos da morfina, meperidina ou fentanil, associados a acepromazina, em caes

If the antihistamines as a class are not effective, the phenothiazines are a good choice.

Nausea and vomiting in pregnancy

(11) Wood et al compared antihistamines to phenothiazines, anticholinergics, sympathomimetics, and various combinations.

Vertigo and motion sickness. Part II: pharmacologic treatment

Metoclopramide appears to result in roughly the same incidence of acute dystonic reactions, akathisia, or hypotension as the phenothiazines.

Dopamine antagonists effective for migraine

Substance abuse is another potential contributor to hypothermia; alcohol and drug use (e.g., sedatives or phenothiazines) can suppress vasoconstriction and the shivering response through cutaneous vasodilation, alter decision-making, and decrease awareness of and response to hazardous environmental conditions (3).

These symptoms are seen with overdoses of such drugs as diphenhydramine (Benadryl and other drugs), phenothiazines (Thorazine and others), tricyclic antidepressants (Elavil and others), some stomach products like dicyclomine (Bentyl), and many over the counter cold remedies and sleep aids.

It was just a herbal tea ..

* Antipsychotic agents (phenothiazines, haloperidol).

Medications, sun may not mix

Medications, particularly benzodiazepines, phenothiazines and anti-depressants, have been implicated as a risk factor for falls in patients with dementia [1, 3, 4, 11, 12], via the proposed mechanisms of central sedation, orthostatic hypotension and extra-pyramidal side-effects [13].

Can falls in patients with dementia be prevented?

For instance, phenothiazines detected by TLC screening were being confirmed by GC/MS - a long and tedious process.

Section reengineering to meet rapid volume growth

Abusers of caffeine are likely to be treated with phenothiazines or antidepressants (Winstead, 1976); higher doses of phenothiazines may be prescribed due to the clinician's failure to recognize caffeine's ability to increase catecholamine output (Greden, Fontaine, Lubetsky, & Chamberline, 1978) and observable initial agitation or excitement (Shisslak, Beutler, Scheiber, Gaines, La Wall, & Crago, 1985).